Endocytosis is a critical step in the process by which many therapeutic nanomedicines reach
their intracellular targets. Our understanding of cellular uptake mechanisms has developed …

Clathrin-mediated endocytosis is the endocytic portal into cells through which cargo is
packaged into vesicles with the aid of a clathrin coat. It is fundamental to neurotransmission …

The extent to which microorganisms impair wound healing is an ongoing controversy in the
management of chronic wounds. Because the high diversity and extreme variability of the …

Dynamin, the founding member of a family of dynamin-like proteins (DLPs) implicated in
membrane remodelling, has a critical role in endocytic membrane fission events. The use of …

Clathrin is a molecular scaffold for vesicular uptake of cargo at the plasma membrane,
where its assembly into cage-like lattices underlies the clathrin-coated pits of classical …

Endocytic mechanisms control the lipid and protein composition of the plasma membrane,
thereby regulating how cells interact with their environments. Here, we review what is known …

Of the many pathogens that infect humans and animals, a large number use cells of the host
organism as protected sites for replication. To reach the relevant intracellular compartments …

Interkingdom signaling is established in the gastrointestinal tract in that human hormones
trigger responses in bacteria; here, we show that the corollary is true, that a specific bacterial …

Peroxisomes have long been established to play a central role in regulating various
metabolic activities in mammalian cells. These organelles act in concert with mitochondria to …

Clathrin-mediated endocytosis (CME) regulates many cell physiological processes such as
the internalization of growth factors and receptors, entry of pathogens, and synaptic …