The microenvironment is indispensable for functionality of various biomacromolecules,
subcellular compartments, living cells, and organisms. In particular, physical properties …

Emerging from the origins of supramolecular chemistry and the development of selective
chemical receptors that rely on lock‐and‐key binding, activity‐based sensing (ABS)—which …

Current electrophysiological or optical techniques cannot reliably perform simultaneous
intracellular recordings from more than a few tens of neurons. Here we report a …

Discoveries in quantum materials, which are characterized by the strongly quantum-
mechanical nature of electrons and atoms, have revealed exotic properties that arise from …

This paper describes the design and synthesis of a photostable, far-red to near-infrared
(NIR) platform for optical voltage sensing. We developed a new, sulfonated silicon …

As a “holy grail” of neuroscience, optical imaging of membrane potential could enable high
resolution measurements of spiking and synaptic activity in neuronal populations. This has …

The formal replacement of one dialkylamino group in rhodamines with a hydroxyl group
transforms them into rhodols. This apparently minor difference is not as small as one may …

Conspectus Membrane potential is a fundamental biophysical property maintained by every
cell on earth. In specialized cells like neurons, rapid changes in membrane potential drive …

Success in the projects aimed at providing an advanced understanding of the brain is
directly predicated on making critical advances in nanotechnology. This Perspective …

Fluorophores based on the BODIPY scaffold are prized for their tunable excitation and
emission profiles, mild syntheses, and biological compatibility. Improving the water-solubility …