Bruton's tyrosine kinase (BTK) is a key component of B cell receptor (BCR) signalling and
functions as an important regulator of cell proliferation and cell survival in various B cell …

Bruton's tyrosine kinase (BTK) was initially discovered as a critical mediator of B cell
receptor signaling in the development and functioning of adaptive immunity. Growing …

In the last few decades, there has been a growing interest in Bruton's tyrosine kinase (BTK)
and the compounds that target it. BTK is a downstream mediator of the B-cell receptor (BCR) …

Cancers are the group of diseases, which arise because of the uncontrolled behavior of
some of the genes in our cells. There are possibilities of gene amplifications …

Cancer immunotherapy has gained traction in recent years owing to remarkable tumor
clearance in some patients. Despite the notable success of immune checkpoint blockade …

Bruton's Tyrosine Kinase (BTK) is considered crucial in the activation and survival of both
physiological and malignant B-cells. In recent years, ibrutinib, an oral BTK inhibitor, became …

Simple Summary Drug resistance is the “Achilles' heel” in current oncology. In this sense,
the clinical management of HER2 breast carcinomas (tumors with overexpression …

The NLRP3 inflammasome represents a critical inflammatory machinery driving pathology in
many acute (eg, myocardial infarction or stroke) and chronic (Alzheimer's disease …

Non-invasive measurement of drug-target engagement can provide critical insights in the
molecular pharmacology of small molecule drugs. Fluorescence polarization/fluorescence …

Bruton's tyrosine kinase (BTK) is a soluble tyrosine kinase with central roles in the
development, maturation, and signaling of B cells. BTK has been found to regulate cell …