Cell migration is a highly dynamic process driven by the cytoskeleton, which mainly
comprises the actin microfilaments, microtubules, and intermediate filaments. During …

Ras homology (RHO) GTPases are signalling proteins that have crucial roles in triggering
multiple immune functions. Through their interactions with a broad range of effectors and …

During cell migration and polarization, numerous signal transduction and cytoskeletal
components self-organize to generate localized protrusions. Although biochemical and …

Dynamic rearrangement of the actin cytoskeleton drives a myriad of processes in eukaryotic
cells, such as cell migration and vesicle trafficking, and its dysregulation is deeply …

Abstract The Rho-family GTPase Rac1 activates the WAVE regulatory complex (WRC) to
drive Arp2/3 complex-mediated actin polymerization in many essential processes. Rac1 …

The tightly coordinated, spatiotemporal control of actin filament remodeling provides the
basis of fundamental cellular processes, such as cell migration and adhesion. Specific …

Abstract Proteins of the Wiskott-Aldrich syndrome protein (WASP) family play a central role
in regulating actin cytoskeletal dynamics in a wide range of cellular processes. Genetic …

Actin filaments generate mechanical forces that drive membrane movements during
trafficking, endocytosis and cell migration. Reciprocally, adaptations of actin networks to …

Cell migration often involves the formation of sheet-like lamellipodia generated by branched
actin filaments. The branches are initiated when Arp2/3 complex [1] is activated by WAVE …

Actin polymerization is essential for cells to migrate, as well as for various cell biological
processes such as cytokinesis and vesicle traffic. This brief review describes the …