A comprehensive and system review for the pharmacological mechanism of action of rhein, an active anthraquinone ingredient

H Sun, G Luo, D Chen, Z **ang - Frontiers in pharmacology, 2016 - frontiersin.org
Rhein is a major medicinal ingredient isolated from several traditional Chinese medicines,
including Rheum palmatum L., Aloe barbadensis Miller, Cassia angustifolia Vahl., and …

[HTML][HTML] Cassia species: A review of traditional uses, phytochemistry and pharmacology

E Zibaee, B Javadi, Z Sobhani, M Akaberi… - Pharmacological …, 2023 - Elsevier
Cassia species have a long history of utilization in various traditional medicine systems
worldwide, and they are widely consumed for medicinal purposes, particularly the officinal …

Deoxycholic acid-functionalised nanoparticles for oral delivery of rhein

W Yao, Z Xu, J Sun, J Luo, Y Wei, J Zou - European Journal of …, 2021 - Elsevier
Rhein (RH) is a candidate for the treatment of kidney diseases. However, clinical application
of RH is impeded by low aqueous solubility and oral bioavailability. Deoxycholic acid …

Secretory clusterin promotes oral cancer cell survival via inhibiting apoptosis by activation of autophagy in AMPK/mTOR/ULK1 dependent pathway

PP Naik, S Mukhopadhyay, PP Praharaj, CS Bhol… - Life sciences, 2021 - Elsevier
Aims Secretory clusterin (sCLU) plays an important role in tumor development and cancer
progression. However, the molecular mechanisms and physiological functions of sCLU in …

Waterless Dyeing and In Vitro Toxicological Properties of Biocolorants from Cortinarius sanguineus

M Herrala, J Yli-Öyrä, AF de Albuquerque… - Journal of Fungi, 2022 - mdpi.com
As a part of an ongoing interest in identifying environmentally friendly alternatives to
synthetic dyes and in using liquid CO2 as a waterless medium for applying the resulting …

Rhein reverses doxorubicin resistance in SMMC‐7721 liver cancer cells by inhibiting energy metabolism and inducing mitochondrial permeability transition pore …

L Wu, K Cao, Z Ni, S Wang, W Li, X Liu, Z Chen - Biofactors, 2019 - Wiley Online Library
Rhein, a monomeric anthraquinone obtained from the plant herb species Polygonum
multiflorum and P. cuspidatum, has been proposed to have anticancer activity. This activity …

Toxicity of naturally occurring anthraquinones

V Shukla, S Asthana, P Gupta, PD Dwivedi… - Advances in molecular …, 2017 - Elsevier
Among the vast array of secondary metabolites produced by plants, anthraquinones (AQs)
are the group of compounds produced by different plants of various families such as …

Liver toxicity of anthraquinones: A combined in vitro cytotoxicity and in silico reverse dosimetry evaluation

Y Liu, MST Mapa, RL Sprando - Food and Chemical Toxicology, 2020 - Elsevier
Anthraquinones are found in a variety of consumer products such as dietary supplements,
traditional Chinese medicines, and drugs. Along with their widespread use, potential safety …

Simulation study of the pH sensitive directed self-assembly of rheins for sustained drug release hydrogel

YH Feng, XP Zhang, YY Hao, GY Ren… - Colloids and Surfaces B …, 2020 - Elsevier
The hydrogel formed by the directed self-assembled rhein molecules at an appropriate pH
value for sustained drug release has been reported recently. Although the application in …

Insights into the modulatory role of cyclosporine A and its research advances in acute inflammation

Q Gui, Z Jiang, L Zhang - International Immunopharmacology, 2021 - Elsevier
Cyclosporine A (CsA), a classic immunosuppressant, is mainly applied for solid organ
transplantation and some autoimmune diseases by suppressing T lymphocytes. Early …