Stroke is the second highest reason of death in the world and the leading cause of disability.
The ischemic stroke makes up the majority of stroke cases that occur due to the blockage of …

Glutamate excitotoxicity is a primary contributor of ischemic neuronal death and other
cellular components of the neurovascular unit. Several strategies have been developed …

Background Mitochondrial organelles play a crucial role in cellular metabolism so different
cell types exhibit diverse metabolic and energy demands. Therefore, alternations in the …

The advent of epigenetics brought in a tectonic shift in the understanding of molecular basis
of complex diseases like ischemic stroke (IS). Substantial scientific inquiry into the …

Much work has been carried out in recent years showing that elevated glutamate levels in
the extracellular environment of the central nervous system play a pivotal role in …

Background Glutamate oxaloacetate transaminase 1 (GOT1) regulates cellular metabolism
through coordinating the utilization of carbohydrates and amino acids to meet nutrient …

Ischemia reperfusion (IR) injury may be attenuated through succinate dehydrogenase (SDH)
inhibition by dimethyl malonate (DiMAL). Whether SDH inhibition yields protection in …

Oxaloacetic acid (OA) is naturally found in organisms and well known as an intermediate of
citric acid cycle producing ATP. We evaluated the effects of OA on tyrosinase activity and …

Objective Blood/brain‐glutamate grabbing is an emerging concept in the treatment of acute
ischemic stroke, where essentially the deleterious effects of glutamate after ischemia are …

Objective (s): Stroke is the most common neurological disorder and genetic susceptibility
has an important role in its etiology. Polymorphism in several genes such as lipoprotein …