Abstract cGMP controls many cellular functions ranging from growth, viability, and
differentiation to contractility, secretion, and ion transport. The mammalian genome encodes …

The intestinal epithelium is a multicellular interface in close proximity to a dense microbial
milieu that is completely renewed every 3–5 days. Pluripotent stem cells reside at the crypt …

Pseudokinases are members of the protein kinase superfamily but signal primarily through
noncatalytic mechanisms. Many pseudokinases contribute to the pathologies of human …

Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), initially identified as a glycolytic
enzyme and considered as a housekee** gene, is widely used as an internal control in …

Obesity is a growing pandemic, and related health and economic costs are staggering.
Pharmacotherapy, partnered with lifestyle modifications, forms the core of current strategies …

Functional gastrointestinal disorders (FGIDs) and IBDs are two of the most prevalent
disorders of the GI tract and consume a significant proportion of healthcare resources …

Intestinal enteroendocrine cells are critical to central regulation of caloric consumption, since
they activate hypothalamic circuits that decrease appetite and thereby restrict meal size by …

Introduction: In men, lower urinary tract symptoms (LUTS) are primarily attributed to benign
prostatic hyperplasia (BPH). Therapeutic options are targeted to relax prostate smooth …

Carvacrol and thymol (CAT) have been widely recognized for their antimicrobial and anti‐
inflammatory properties, yet their specific effects on colitis and the mechanisms involved …

Despite novel technologies, colon cancer remains undiagnosed and 25% of patients are
diagnosed with metastatic colon cancer. Resistant to chemotherapeutic agents is one of the …