Pleiotropy and specificity: insights from the interleukin 6 family of cytokines

M Murakami, D Kamimura, T Hirano - Immunity, 2019 - cell.com
Since the molecular cloning of interleukin-6 (IL-6) in 1986, many other cytokines have been
found to share the same signal transducer, gp130, in their receptor complexes. Thus, the IL …

Tissue engineering for clean meat production

T Ben-Arye, S Levenberg - Frontiers in Sustainable Food Systems, 2019 - frontiersin.org
Increasing public awareness of foodborne illnesses, factory farming, and the ecological
footprint of the meat industry, has generated the need for animal-free meat alternatives. In …

A targetable LIFR− NF-κB− LCN2 axis controls liver tumorigenesis and vulnerability to ferroptosis

F Yao, Y Deng, Y Zhao, Y Mei, Y Zhang, X Liu… - Nature …, 2021 - nature.com
The growing knowledge of ferroptosis has suggested the role and therapeutic potential of
ferroptosis in cancer, but has not been translated into effective therapy. Liver cancer …

Targeting LIF-mediated paracrine interaction for pancreatic cancer therapy and monitoring

Y Shi, W Gao, NK Lytle, P Huang, X Yuan, AM Dann… - Nature, 2019 - nature.com
Pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis largely owing to
inefficient diagnosis and tenacious drug resistance. Activation of pancreatic stellate cells …

LIF signaling regulates outer radial glial to interneuron fate during human cortical development

MG Andrews, C Siebert, L Wang, ML White, J Ross… - Cell stem cell, 2023 - cell.com
Radial glial (RG) development is essential for cerebral cortex growth and organization. In
humans, the outer radial glia (oRG) subtype is expanded and gives rise to diverse neurons …

Sarcopenia and cognitive function: role of myokines in muscle brain cross-talk

L Scisciola, RA Fontanella, Surina, V Cataldo… - Life, 2021 - mdpi.com
Sarcopenia is a geriatric syndrome characterized by the progressive degeneration of muscle
mass and function, and it is associated with severe complications, which are falls, functional …

STAT3 phosphorylation at Ser727 and Tyr705 differentially regulates the EMT–MET switch and cancer metastasis

WH Lin, YW Chang, MX Hong, TC Hsu, KC Lee, C Lin… - Oncogene, 2021 - nature.com
Abstract Epithelial–mesenchymal transition (EMT)/mesenchymal–epithelial transition (MET)
processes are proposed to be a driving force of cancer metastasis. By studying metastasis in …

Progesterone as an anti-inflammatory drug and immunomodulator: new aspects in hormonal regulation of the inflammation

TA Fedotcheva, NI Fedotcheva, NL Shimanovsky - Biomolecules, 2022 - mdpi.com
The specific regulation of inflammatory processes by steroid hormones has been actively
studied in recent years, especially by progesterone (P4) and progestins. The mechanisms of …

Development of a Chemically Defined Medium for in vitro Expansion of Primary Bovine Satellite Cells

AM Kolkmann, A Van Essen, MJ Post… - … in bioengineering and …, 2022 - frontiersin.org
The use of fetal bovine serum (FBS) in animal cell culture media is widely spread since it
provides a broad spectrum of molecules that are known to support cell attachment and …

The role of interleukin-6 family members in cardiovascular diseases

Y Feng, D Ye, Z Wang, H Pan, X Lu, M Wang… - Frontiers in …, 2022 - frontiersin.org
Cardiovascular disease is one of the main causes of human mortality. Cytokines play crucial
roles in the development of cardiovascular disease. Interleukin (IL)-6 family members are a …