Stress is a disturbance in homeostasis caused by psychological, physiological, or
environmental factors. Prolonged reactions to chronic stress can be detrimental, resulting in …

Major depression is one of the leading causes of premature death and disability. Although
available drugs are effective, they also have substantial limitations. Recent advances in our …

Gender differences in patients with borderline personality disorder are potentially relevant
because they may guide clinicians in assessment and treatment. To date, a number of …

Objective To systematically review published and unpublished efficacy studies of
agomelatine in people with depression. Design Systematic review and meta-analysis. Data …

Current antidepressants used in major depressive disorder (MDD) are still not efficacious
enough for many patients due to high levels of treatment resistance and bothersome side …

Major depressive disorder constitutes one of the leading causes of disability worldwide.
However, it is not a unitary disease—it is a heterogeneous syndrome, with patients differing …

Objective This randomised, double‐blind, 12‐week study compared efficacy and tolerability
of flexible‐dose treatment with vortioxetine (10–20 mg/day) versus agomelatine (25–50 …

Most organisms (including humans) developed daily rhythms in almost every aspect of their
body. It is not surprising that rhythms are also related to affect in health and disease. In the …

Background The type and quantities of antidepressants are increasing, but the efficacy and
safety of first-line and emerging drugs vary between studies. In this article, we estimated the …

This open study evaluates the effect of agomelatine, a melatonergic receptor agonist and 5-
HT2C antagonist antidepressant, on sleep architecture in patients suffering from major …