The immunology of Parkinson's disease

B Zhu, D Yin, H Zhao, L Zhang - Seminars in immunopathology, 2022 - Springer
Parkinson's disease (PD) is the second most common neurodegenerative disorder which
affects 6.1 million people worldwide. The neuropathological hallmarks include the loss of …

Alpha and beta synucleins: from pathophysiology to clinical application as biomarkers

L Barba, F Paolini Paoletti, G Bellomo… - Movement …, 2022 - Wiley Online Library
The synuclein family includes three neuronal proteins, named α‐synuclein, β‐synuclein, and
γ‐synuclein, that have peculiar structural features. α‐synuclein is largely known for being a …

[HTML][HTML] Gut microbiome and Parkinson's disease: Perspective on pathogenesis and treatment

S Salim, F Ahmad, A Banu, F Mohammad - Journal of Advanced Research, 2023 - Elsevier
Background Parkinson's disease (PD) is a disease of⍺-synuclein aggregation-mediated
dopaminergic neuronal loss in the substantia nigra pars compacta, which leads to motor and …

Alpha synuclein connects the gut-brain axis in Parkinson's disease patients–a view on clinical aspects, cellular pathology and analytical methodology

E Schaeffer, A Kluge, M Böttner, F Zunke… - Frontiers in cell and …, 2020 - frontiersin.org
Parkinson's disease (PD) is marked by different kinds of pathological features, one hallmark
is the aggregation of α-synuclein (aSyn). The development of aSyn pathology in the …

The Gut–Brain Axis in Parkinson's Disease

V Gao, CV Crawford, J Burré - Cold Spring …, 2025 - perspectivesinmedicine.cshlp.org
Parkinson's disease (PD) involves both the central nervous system (CNS) and enteric
nervous system (ENS), and their interaction is important for understanding both the clinical …

Velusetrag rescues GI dysfunction, gut inflammation and dysbiosis in a mouse model of Parkinson's disease

J Grigoletto, F Miraglia, L Benvenuti… - npj Parkinson's …, 2023 - nature.com
In patients with Parkinson's disease (PD), constipation is common, and it appears in a
prodromal stage before the hallmark motor symptoms. The present study aimed to …

Multisystem screening reveals SARS‐CoV‐2 in neurons of the myenteric plexus and in megakaryocytes

S Gray‐Rodriguez, MP Jensen… - The Journal of …, 2022 - Wiley Online Library
Abstract SARS‐CoV‐2, the causative agent of COVID‐19, typically manifests as a
respiratory illness, although extrapulmonary involvement, such as in the gastrointestinal tract …

The pathological mechanism between the intestine and brain in the early stage of Parkinson's disease

R Yang, G Gao, H Yang - Frontiers in Aging Neuroscience, 2022 - frontiersin.org
Parkinson's disease (PD) is the second most common chronic progressive
neurodegenerative disease. The main pathological features are progressive degeneration …

Immunohistochemical expression and neurochemical phenotypes of huntingtin-associated protein 1 in the myenteric plexus of mouse gastrointestinal tract

AMM Tarif, MN Islam, MR Jahan, A Yanai… - Cell and Tissue …, 2021 - Springer
Abstract Huntingtin-associated protein 1 (HAP1) is a neural huntingtin interactor and being
considered as a core molecule of stigmoid body (STB). Brain/spinal cord regions with …

Brazil nut-enriched diet modulates enteric glial cells and gut microbiota in an experimental model of chronic kidney disease

PP Almeida, BO Da Cruz, B Thomasi… - Journal of the …, 2024 - Taylor & Francis
Introduction: Chronic kidney disease (CKD) promotes gut dysbiosis, and enteric glial
reactivity, a feature of intestinal inflammation. Brazil nut modulated enteric glial profile in …