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The immunology of Parkinson's disease
Parkinson's disease (PD) is the second most common neurodegenerative disorder which
affects 6.1 million people worldwide. The neuropathological hallmarks include the loss of …
affects 6.1 million people worldwide. The neuropathological hallmarks include the loss of …
Alpha and beta synucleins: from pathophysiology to clinical application as biomarkers
The synuclein family includes three neuronal proteins, named α‐synuclein, β‐synuclein, and
γ‐synuclein, that have peculiar structural features. α‐synuclein is largely known for being a …
γ‐synuclein, that have peculiar structural features. α‐synuclein is largely known for being a …
[HTML][HTML] Gut microbiome and Parkinson's disease: Perspective on pathogenesis and treatment
Background Parkinson's disease (PD) is a disease of⍺-synuclein aggregation-mediated
dopaminergic neuronal loss in the substantia nigra pars compacta, which leads to motor and …
dopaminergic neuronal loss in the substantia nigra pars compacta, which leads to motor and …
Alpha synuclein connects the gut-brain axis in Parkinson's disease patients–a view on clinical aspects, cellular pathology and analytical methodology
E Schaeffer, A Kluge, M Böttner, F Zunke… - Frontiers in cell and …, 2020 - frontiersin.org
Parkinson's disease (PD) is marked by different kinds of pathological features, one hallmark
is the aggregation of α-synuclein (aSyn). The development of aSyn pathology in the …
is the aggregation of α-synuclein (aSyn). The development of aSyn pathology in the …
The Gut–Brain Axis in Parkinson's Disease
Parkinson's disease (PD) involves both the central nervous system (CNS) and enteric
nervous system (ENS), and their interaction is important for understanding both the clinical …
nervous system (ENS), and their interaction is important for understanding both the clinical …
Velusetrag rescues GI dysfunction, gut inflammation and dysbiosis in a mouse model of Parkinson's disease
J Grigoletto, F Miraglia, L Benvenuti… - npj Parkinson's …, 2023 - nature.com
In patients with Parkinson's disease (PD), constipation is common, and it appears in a
prodromal stage before the hallmark motor symptoms. The present study aimed to …
prodromal stage before the hallmark motor symptoms. The present study aimed to …
Multisystem screening reveals SARS‐CoV‐2 in neurons of the myenteric plexus and in megakaryocytes
S Gray‐Rodriguez, MP Jensen… - The Journal of …, 2022 - Wiley Online Library
Abstract SARS‐CoV‐2, the causative agent of COVID‐19, typically manifests as a
respiratory illness, although extrapulmonary involvement, such as in the gastrointestinal tract …
respiratory illness, although extrapulmonary involvement, such as in the gastrointestinal tract …
The pathological mechanism between the intestine and brain in the early stage of Parkinson's disease
R Yang, G Gao, H Yang - Frontiers in Aging Neuroscience, 2022 - frontiersin.org
Parkinson's disease (PD) is the second most common chronic progressive
neurodegenerative disease. The main pathological features are progressive degeneration …
neurodegenerative disease. The main pathological features are progressive degeneration …
Immunohistochemical expression and neurochemical phenotypes of huntingtin-associated protein 1 in the myenteric plexus of mouse gastrointestinal tract
Abstract Huntingtin-associated protein 1 (HAP1) is a neural huntingtin interactor and being
considered as a core molecule of stigmoid body (STB). Brain/spinal cord regions with …
considered as a core molecule of stigmoid body (STB). Brain/spinal cord regions with …
Brazil nut-enriched diet modulates enteric glial cells and gut microbiota in an experimental model of chronic kidney disease
PP Almeida, BO Da Cruz, B Thomasi… - Journal of the …, 2024 - Taylor & Francis
Introduction: Chronic kidney disease (CKD) promotes gut dysbiosis, and enteric glial
reactivity, a feature of intestinal inflammation. Brazil nut modulated enteric glial profile in …
reactivity, a feature of intestinal inflammation. Brazil nut modulated enteric glial profile in …