Mechanisms of biological effects of ionic liquids: from single cells to multicellular organisms

KS Egorova, AV Kibardin, AV Posvyatenko… - Chemical …, 2024 - ACS Publications
The review presents a detailed discussion of the evolving field studying interactions
between ionic liquids (ILs) and biological systems. Originating from molten salt electrolytes …

Toward the proactive design of sustainable chemicals: Ionic liquids as a prime example

S Beil, M Markiewicz, CS Pereira, P Stepnowski… - Chemical …, 2021 - ACS Publications
The tailorable and often unique properties of ionic liquids (ILs) drive their implementation
into a broad variety of seminal technologies. The modular design of ILs allows in this context …

Toxicity of ionic liquids: eco (cyto) activity as complicated, but unavoidable parameter for task‐specific optimization

KS Egorova, VP Ananikov - ChemSusChem, 2014 - Wiley Online Library
Rapid progress in the field of ionic liquids in recent decades led to the development of many
outstanding energy‐conversion processes, catalytic systems, synthetic procedures, and …

Expression of organic anion transporter 2 in the human kidney and its potential role in the tubular secretion of guanine-containing antiviral drugs

Y Cheng, A Vapurcuyan, M Shahidullah… - Drug Metabolism and …, 2012 - Elsevier
The organic anion transporters 1 and 3 (OAT1 and OAT3) and organic cation transporter 2
(OCT2) are important for renal tubular drug secretion. In contrast, evidence for OAT2 …

TICBase: integrated resource for data on drug and environmental chemical interactions with mammalian drug transporters

ME Michel, CC Wen, SW Yee… - Clinical …, 2023 - Wiley Online Library
Environmental health science seeks to predict how environmental toxins, chemical toxicants,
and prescription drugs accumulate and interact within the body. Xenobiotic transporters of …

Substrate-dependent inhibition of human MATE1 by cationic ionic liquids

LJ Martínez-Guerrero, SH Wright - The Journal of pharmacology and …, 2013 - Elsevier
The multidrug and toxin extruders 1-and 2-K (MATE1 and MATE2-K) are expressed in the
luminal membrane of renal proximal tubule cells and provide the active step in the secretion …

Assay conditions influence affinities of rat organic cation transporter 1: analysis of mutagenesis in the modeled outward-facing cleft by measuring effects of substrates …

V Gorboulev, S Rehman, CM Albert, U Roth… - Molecular …, 2018 - Elsevier
The effects of mutations in the modeled outward-open cleft of rat organic cation transporter 1
(rOCT1) on affinities of substrates and inhibitors were investigated. Human embryonic …

Combinatorial pharmacophore modeling of organic cation transporter 2 (OCT2) inhibitors: insights into multiple inhibitory mechanisms

Y Xu, X Liu, S Li, N Zhou, L Gong, C Luo… - Molecular …, 2013 - ACS Publications
Organic cation transporter 2 (OCT2) is responsible for the entry step of many drugs in renal
elimination, of which the changing activity may cause unwanted drug–drug interactions …

Development of an LC–MS/MS method for high throughput quantification of metformin uptake in transporter inhibition assays

M Vath, L Gallagher, W Shou, H Weller, L Elkin… - … of Chromatography B, 2014 - Elsevier
Abstract A high throughput LC–MS/MS method for quantification of metformin substrate
uptake enables conversion of radiometric transporter inhibition assays for multidrug and …

Potent inhibition of human organic cation transporter 2 (hOCT2) by β-carboline alkaloids

DJ Wagner, H Duan, A Chapron, RW Lee, J Wang - Xenobiotica, 2017 - Taylor & Francis
Beta-carbolines are indole alkaloids with a wide range of pharmacological and toxicological
activities. Beta-carbolines are structurally related to the neurotoxin 1-methyl-4 …