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Mechanisms of biological effects of ionic liquids: from single cells to multicellular organisms
KS Egorova, AV Kibardin, AV Posvyatenko… - Chemical …, 2024 - ACS Publications
The review presents a detailed discussion of the evolving field studying interactions
between ionic liquids (ILs) and biological systems. Originating from molten salt electrolytes …
between ionic liquids (ILs) and biological systems. Originating from molten salt electrolytes …
Toward the proactive design of sustainable chemicals: Ionic liquids as a prime example
The tailorable and often unique properties of ionic liquids (ILs) drive their implementation
into a broad variety of seminal technologies. The modular design of ILs allows in this context …
into a broad variety of seminal technologies. The modular design of ILs allows in this context …
Toxicity of ionic liquids: eco (cyto) activity as complicated, but unavoidable parameter for task‐specific optimization
Rapid progress in the field of ionic liquids in recent decades led to the development of many
outstanding energy‐conversion processes, catalytic systems, synthetic procedures, and …
outstanding energy‐conversion processes, catalytic systems, synthetic procedures, and …
Expression of organic anion transporter 2 in the human kidney and its potential role in the tubular secretion of guanine-containing antiviral drugs
Y Cheng, A Vapurcuyan, M Shahidullah… - Drug Metabolism and …, 2012 - Elsevier
The organic anion transporters 1 and 3 (OAT1 and OAT3) and organic cation transporter 2
(OCT2) are important for renal tubular drug secretion. In contrast, evidence for OAT2 …
(OCT2) are important for renal tubular drug secretion. In contrast, evidence for OAT2 …
TICBase: integrated resource for data on drug and environmental chemical interactions with mammalian drug transporters
ME Michel, CC Wen, SW Yee… - Clinical …, 2023 - Wiley Online Library
Environmental health science seeks to predict how environmental toxins, chemical toxicants,
and prescription drugs accumulate and interact within the body. Xenobiotic transporters of …
and prescription drugs accumulate and interact within the body. Xenobiotic transporters of …
Substrate-dependent inhibition of human MATE1 by cationic ionic liquids
LJ Martínez-Guerrero, SH Wright - The Journal of pharmacology and …, 2013 - Elsevier
The multidrug and toxin extruders 1-and 2-K (MATE1 and MATE2-K) are expressed in the
luminal membrane of renal proximal tubule cells and provide the active step in the secretion …
luminal membrane of renal proximal tubule cells and provide the active step in the secretion …
Assay conditions influence affinities of rat organic cation transporter 1: analysis of mutagenesis in the modeled outward-facing cleft by measuring effects of substrates …
V Gorboulev, S Rehman, CM Albert, U Roth… - Molecular …, 2018 - Elsevier
The effects of mutations in the modeled outward-open cleft of rat organic cation transporter 1
(rOCT1) on affinities of substrates and inhibitors were investigated. Human embryonic …
(rOCT1) on affinities of substrates and inhibitors were investigated. Human embryonic …
Combinatorial pharmacophore modeling of organic cation transporter 2 (OCT2) inhibitors: insights into multiple inhibitory mechanisms
Y Xu, X Liu, S Li, N Zhou, L Gong, C Luo… - Molecular …, 2013 - ACS Publications
Organic cation transporter 2 (OCT2) is responsible for the entry step of many drugs in renal
elimination, of which the changing activity may cause unwanted drug–drug interactions …
elimination, of which the changing activity may cause unwanted drug–drug interactions …
Development of an LC–MS/MS method for high throughput quantification of metformin uptake in transporter inhibition assays
Abstract A high throughput LC–MS/MS method for quantification of metformin substrate
uptake enables conversion of radiometric transporter inhibition assays for multidrug and …
uptake enables conversion of radiometric transporter inhibition assays for multidrug and …
Potent inhibition of human organic cation transporter 2 (hOCT2) by β-carboline alkaloids
DJ Wagner, H Duan, A Chapron, RW Lee, J Wang - Xenobiotica, 2017 - Taylor & Francis
Beta-carbolines are indole alkaloids with a wide range of pharmacological and toxicological
activities. Beta-carbolines are structurally related to the neurotoxin 1-methyl-4 …
activities. Beta-carbolines are structurally related to the neurotoxin 1-methyl-4 …