Over the past decade, PAS domains have been identified in dozens of signal transduction
molecules and various forms have been found in animals, plants, and prokaryotes. In this …

The insulin-like growth factor (IGF) signaling pathway consists of multiple IGF ligands, IGF
receptors, and IGF-binding proteins (IGFBPs). Studies in a variety of animal and cellular …

Much of the work conducted on adult stem cells has focused on mesenchymal stem cells
(MSCs) found within the bone marrow stroma. Adipose tissue, like bone marrow, is derived …

Mice deficient in C/EBPα have defective development of adipose tissue, but the precise role
of C/EBPα has not been defined. Fibroblasts from C/EBPα (−/−) mice undergo adipose …

The murine homeo box gene Nkx2-5 is expressed in precardiac mesoderm and in the
myocardium of embryonic and fetal hearts. Targeted interruption of Nkx2-5 resulted in …

Skeletal muscle differentiation entails the coordination of muscle-specific gene expression
and terminal withdrawal from the cell cycle. This cell cycle arrest in the G0 phase requires …

Members of the myocyte enhancer factor-2 (MEFS) family of MADS domain transcription
factors cannot induce myogenesis in transfected fibroblasts, but when coexpressed with the …

Skeletal muscle and adipose tissue development often has a reciprocal relationship in vivo,
particularly in myodystrophic states. We have investigated whether determined myoblasts …

The extracellular signals which regulate the myogenic program are transduced to the
nucleus by mitogen-activated protein kinases (MAPKs). We have investigated the role of two …

Transcription factors of the bHLH-PAS protein family are important regulators of
developmental processes such as neurogenesis and tracheal development in invertebrates …