Gut microbes from the phylogenetically diverse genus Eubacterium and their various contributions to gut health

A Mukherjee, C Lordan, RP Ross, PD Cotter - Gut microbes, 2020‏ - Taylor & Francis
Over the last two decades our understanding of the gut microbiota and its contribution to
health and disease has been transformed. Among a new 'generation'of potentially beneficial …

Influence of the gut microbiome, diet, and environment on risk of colorectal cancer

M Song, AT Chan, J Sun - Gastroenterology, 2020‏ - Elsevier
Researchers have discovered associations between elements of the intestinal microbiome
(including specific microbes, signaling pathways, and microbiota-related metabolites) and …

Microbially produced imidazole propionate impairs insulin signaling through mTORC1

A Koh, A Molinaro, M Ståhlman, MT Khan, C Schmidt… - Cell, 2018‏ - cell.com
Interactions between the gut microbiota, diet, and the host potentially contribute to the
development of metabolic diseases. Here, we identify imidazole propionate as a microbially …

Gut microbiome affects the response to anti-PD-1 immunotherapy in patients with hepatocellular carcinoma

Y Zheng, T Wang, X Tu, Y Huang, H Zhang… - … for immunotherapy of …, 2019‏ - Springer
Background Checkpoint-blockade immunotherapy targeting programmed cell death protein
1 (PD-1) has recently shown promising efficacy in hepatocellular carcinoma (HCC) …

The human gut microbiome: from association to modulation

TSB Schmidt, J Raes, P Bork - Cell, 2018‏ - cell.com
Our understanding of the human gut microbiome continues to evolve at a rapid pace, but
practical application of thisknowledge is still in its infancy. This review discusses the type of …

Creation and analysis of biochemical constraint-based models using the COBRA Toolbox v. 3.0

L Heirendt, S Arreckx, T Pfau, SN Mendoza… - Nature protocols, 2019‏ - nature.com
Constraint-based reconstruction and analysis (COBRA) provides a molecular mechanistic
framework for integrative analysis of experimental molecular systems biology data and …

The fecal metabolome as a functional readout of the gut microbiome

J Zierer, MA Jackson, G Kastenmüller, M Mangino… - Nature …, 2018‏ - nature.com
The human gut microbiome plays a key role in human health 1, but 16S characterization
lacks quantitative functional annotation 2. The fecal metabolome provides a functional …

Gut microbiota in cardiovascular health and disease

WHW Tang, T Kitai, SL Hazen - Circulation research, 2017‏ - ahajournals.org
Significant interest in recent years has focused on gut microbiota–host interaction because
accumulating evidence has revealed that intestinal microbiota play an important role in …

Molecular phenomics and metagenomics of hepatic steatosis in non-diabetic obese women

L Hoyles, JM Fernández-Real, M Federici, M Serino… - Nature medicine, 2018‏ - nature.com
Hepatic steatosis is a multifactorial condition that is often observed in obese patients and is
a prelude to non-alcoholic fatty liver disease. Here, we combine shotgun sequencing of fecal …

The human intestinal microbiome in health and disease

SV Lynch, O Pedersen - New England journal of medicine, 2016‏ - Mass Medical Soc
The Human Intestinal Microbiome in Health and Disease | New England Journal of Medicine
Skip to main content The New England Journal of Medicine homepage Advanced Search …