Bacterial multidrug efflux pumps have come to prominence in human and veterinary
pathogenesis because they help bacteria protect themselves against the antimicrobials …

Type VII secretion systems (T7SSs) have a key role in the secretion of effector proteins in
non-pathogenic mycobacteria and pathogenic mycobacteria such as Mycobacterium …

Mycobacterium tuberculosis (M. tb) is an intracellular pathogen that exploits moonlighting
functions of its proteins to interfere with host cell functions. PE/PPE proteins utilize host …

Mycobacterium tuberculosis (Mtb) can withstand months of antibiotic treatment. An important
goal of tuberculosis research is to shorten the treatment to reduce the burden on patients …

The tuberculosis necrotizing toxin (TNT) is the major cytotoxicity factor of Mycobacterium
tuberculosis (Mtb) in macrophages. TNT is the C-terminal domain of the outer membrane …

Macrophages are the host cells and the frontline defense against Mycobacterium
tuberculosis (Mtb) infection, and the form of death of infected macrophages plays a pivotal …

The biology of mycobacteria is dominated by a complex cell envelope of unique composition
and structure and of exceptionally low permeability. This cell envelope is the basis of many …

Drug-resistant Mycobacterium tuberculosis is a worldwide health-care problem rendering
current tuberculosis (TB) drugs ineffective. Drug efflux is an important mechanism in …

When one thinks of the Gram+ cell wall, the peptidoglycan (PG) scaffold in particular comes
to mind. However, the cell wall also consists of many other components, for example those …

Iron is essential for growth of Mycobacterium tuberculosis, the causative agent of
tuberculosis. To acquire iron from the host, M. tuberculosis uses the siderophores called …