Molecular farming of pharmaceutical proteins
R Fischer, N Emans - Transgenic research, 2000 - Springer
Molecular farming is the production of pharmaceutically important and commercially
valuable proteins in plants. Its purpose is to provide a safe and inexpensive means for the …
valuable proteins in plants. Its purpose is to provide a safe and inexpensive means for the …
Transgenic plants as protein factories
G Giddings - Current Opinion in Biotechnology, 2001 - Elsevier
Transgenic plants are showing considerable potential for the economic production of
proteins, with a few already being marketed. Recent clinical trials of pharmaceuticals …
proteins, with a few already being marketed. Recent clinical trials of pharmaceuticals …
Transgenic plants in the biopharmaceutical market
Many of our 'small-molecule-drugs' are natural products from plants, or are synthetic
compounds based on molecules found naturally in plants. However, the vast majority of the …
compounds based on molecules found naturally in plants. However, the vast majority of the …
A pollen-specific RALF from tomato that regulates pollen tube elongation
Abstract Rapid Alkalinization Factors (RALFs) are plant peptides that rapidly increase the pH
of plant suspension cell culture medium and inhibit root growth. A pollen-specific tomato …
of plant suspension cell culture medium and inhibit root growth. A pollen-specific tomato …
High‐yield production of authentic human growth hormone using a plant virus‐based expression system
M Gils, R Kandzia, S Marillonnet… - Plant Biotechnology …, 2005 - Wiley Online Library
We describe here a high‐yield transient expression system for the production of human
growth hormone (hGH, or somatotropin) in transfected Nicotiana benthamiana leaves. The …
growth hormone (hGH, or somatotropin) in transfected Nicotiana benthamiana leaves. The …
Expression of human growth hormone in transgenic rice cell suspension culture
TG Kim, MY Baek, EK Lee, TH Kwon, MS Yang - Plant cell reports, 2008 - Springer
Human growth hormone (hGH), a pituitary-derived polypeptide, evidences a wide range of
biological functions, including protein synthesis, cell proliferation, and metabolism. A …
biological functions, including protein synthesis, cell proliferation, and metabolism. A …
High-level expression of human interferon alpha-2b in transgenic carrot (Daucus carota L.) plants
Y Luchakivskaya, O Kishchenko, I Gerasymenko… - Plant cell reports, 2011 - Springer
In this study, we report the obtaining of carrot plants expressing human interferon alpha-2b
via Agrobacterium-mediated transformation using two vector constructs containing the …
via Agrobacterium-mediated transformation using two vector constructs containing the …
Expression and localization of human lysozyme in the endosperm of transgenic rice
In order to understand the characteristics of recombinant protein expression and
sublocalization in rice (Oryza sativa L.) endosperm, we examined the expression level of …
sublocalization in rice (Oryza sativa L.) endosperm, we examined the expression level of …
Commercialization of whole‐plant systems for biomanufacturing of protein products: evolution and prospects
HM Davies - Plant biotechnology journal, 2010 - Wiley Online Library
Technology for enabling plants to biomanufacture nonnative proteins in commercially
significant quantities has been available for just over 20 years. During that time, the …
significant quantities has been available for just over 20 years. During that time, the …
Modification of plant N‐glycans processing: the future of producing therapeutic protein by transgenic plants
M Chen, X Liu, Z Wang, J Song, Q Qi… - Medicinal research …, 2005 - Wiley Online Library
Transgenic plants are regarded as one of the most promising systems for the production of
human therapeutic proteins. The number of therapeutic proteins successfully produced in …
human therapeutic proteins. The number of therapeutic proteins successfully produced in …