Molecular farming of pharmaceutical proteins

R Fischer, N Emans - Transgenic research, 2000 - Springer
Molecular farming is the production of pharmaceutically important and commercially
valuable proteins in plants. Its purpose is to provide a safe and inexpensive means for the …

Transgenic plants as protein factories

G Giddings - Current Opinion in Biotechnology, 2001 - Elsevier
Transgenic plants are showing considerable potential for the economic production of
proteins, with a few already being marketed. Recent clinical trials of pharmaceuticals …

Transgenic plants in the biopharmaceutical market

RM Twyman, S Schillberg, R Fischer - Expert opinion on emerging …, 2005 - Taylor & Francis
Many of our 'small-molecule-drugs' are natural products from plants, or are synthetic
compounds based on molecules found naturally in plants. However, the vast majority of the …

A pollen-specific RALF from tomato that regulates pollen tube elongation

PA Covey, CC Subbaiah, RL Parsons… - Plant …, 2010 - academic.oup.com
Abstract Rapid Alkalinization Factors (RALFs) are plant peptides that rapidly increase the pH
of plant suspension cell culture medium and inhibit root growth. A pollen-specific tomato …

High‐yield production of authentic human growth hormone using a plant virus‐based expression system

M Gils, R Kandzia, S Marillonnet… - Plant Biotechnology …, 2005 - Wiley Online Library
We describe here a high‐yield transient expression system for the production of human
growth hormone (hGH, or somatotropin) in transfected Nicotiana benthamiana leaves. The …

Expression of human growth hormone in transgenic rice cell suspension culture

TG Kim, MY Baek, EK Lee, TH Kwon, MS Yang - Plant cell reports, 2008 - Springer
Human growth hormone (hGH), a pituitary-derived polypeptide, evidences a wide range of
biological functions, including protein synthesis, cell proliferation, and metabolism. A …

High-level expression of human interferon alpha-2b in transgenic carrot (Daucus carota L.) plants

Y Luchakivskaya, O Kishchenko, I Gerasymenko… - Plant cell reports, 2011 - Springer
In this study, we report the obtaining of carrot plants expressing human interferon alpha-2b
via Agrobacterium-mediated transformation using two vector constructs containing the …

Expression and localization of human lysozyme in the endosperm of transgenic rice

D Yang, F Guo, B Liu, N Huang, SC Watkins - Planta, 2003 - Springer
In order to understand the characteristics of recombinant protein expression and
sublocalization in rice (Oryza sativa L.) endosperm, we examined the expression level of …

Commercialization of whole‐plant systems for biomanufacturing of protein products: evolution and prospects

HM Davies - Plant biotechnology journal, 2010 - Wiley Online Library
Technology for enabling plants to biomanufacture nonnative proteins in commercially
significant quantities has been available for just over 20 years. During that time, the …

Modification of plant N‐glycans processing: the future of producing therapeutic protein by transgenic plants

M Chen, X Liu, Z Wang, J Song, Q Qi… - Medicinal research …, 2005 - Wiley Online Library
Transgenic plants are regarded as one of the most promising systems for the production of
human therapeutic proteins. The number of therapeutic proteins successfully produced in …