Cachexia: A systemic consequence of progressive, unresolved disease

M Ferrer, TG Anthony, JS Ayres, G Biffi, JC Brown… - Cell, 2023 - cell.com
Cachexia, a systemic wasting condition, is considered a late consequence of diseases,
including cancer, organ failure, or infections, and contributes to significant morbidity and …

[HTML][HTML] A review of sarcopenia pathophysiology, diagnosis, treatment and future direction

MR Cho, S Lee, SK Song - Journal of Korean medical …, 2022 - synapse.koreamed.org
Sarcopenia is a progressive and generalized loss of skeletal muscle mass and function. The
prevalence of sarcopenia was reported to be up to 29% in older persons in the community …

Ponsegromab for the treatment of cancer cachexia

JD Groarke, J Crawford, SM Collins… - … England Journal of …, 2024 - Mass Medical Soc
Background Cachexia is a common complication of cancer and is associated with an
increased risk of death. The level of growth differentiation factor 15 (GDF-15), a circulating …

Guidance for assessment of the muscle mass phenotypic criterion for the Global Leadership Initiative on Malnutrition (GLIM) diagnosis of malnutrition

R Barazzoni, GL Jensen, MITD Correia, MC Gonzalez… - Clinical Nutrition, 2022 - Elsevier
Summary The Global Leadership Initiative on Malnutrition (GLIM) provides consensus
criteria for the diagnosis of malnutrition that can be widely applied. The GLIM approach is …

The spectrum of malnutrition/cachexia/sarcopenia in oncology according to different cancer types and settings: a narrative review

P Bossi, P Delrio, A Mascheroni, M Zanetti - Nutrients, 2021 - mdpi.com
Nutritional status in oncological patients may differ according to several modifiable and non-
modifiable factors. Knowledge of the epidemiology of malnutrition/cachexia/sarcopenia may …

[HTML][HTML] Cancer cachexia in adult patients: ESMO Clinical Practice Guidelines☆

J Arends, F Strasser, S Gonella, TS Solheim… - ESMO open, 2021 - Elsevier
Cachexia remains an underdiagnosed and undertreated, complex condition which includes
'objective'components (eg inadequate food intake, weight loss, inactivity, loss of muscle …

Sarcopenia: revised European consensus on definition and diagnosis

AJ Cruz-Jentoft, G Bahat, J Bauer, Y Boirie… - Age and …, 2019 - academic.oup.com
Abstract Background in 2010, the European Working Group on Sarcopenia in Older People
(EWGSOP) published a sarcopenia definition that aimed to foster advances in identifying …

Sarcopenia in the older adult with cancer

GR Williams, RF Dunne, S Giri… - Journal of Clinical …, 2021 - pmc.ncbi.nlm.nih.gov
The term sarcopenia, derived from the Greek words sarx for flesh and penia for loss, was first
introduced by Rosenberg 1 in 1989 to describe the loss of muscle mass that accompanies …

[HTML][HTML] Early detection of pancreatic cancer: opportunities and challenges

AD Singhi, EJ Koay, ST Chari, A Maitra - Gastroenterology, 2019 - Elsevier
Most patients with pancreatic ductal adenocarcinoma (PDAC) present with symptomatic,
surgically unresectable disease. Although the goal of early detection of PDAC is laudable …

Fasting and cancer: molecular mechanisms and clinical application

A Nencioni, I Caffa, S Cortellino, VD Longo - Nature Reviews Cancer, 2018 - nature.com
The vulnerability of cancer cells to nutrient deprivation and their dependency on specific
metabolites are emerging hallmarks of cancer. Fasting or fasting-mimicking diets (FMDs) …