Current approaches to the management of brain metastases
Brain metastases are a very common manifestation of cancer that have historically been
approached as a single disease entity given the uniform association with poor clinical …
approached as a single disease entity given the uniform association with poor clinical …
Brain metastases
AS Achrol, RC Rennert, C Anders, R Soffietti… - Nature Reviews …, 2019 - nature.com
An estimated 20% of all patients with cancer will develop brain metastases, with the majority
of brain metastases occurring in those with lung, breast and colorectal cancers, melanoma …
of brain metastases occurring in those with lung, breast and colorectal cancers, melanoma …
Treatment strategies for breast cancer brain metastases
C Bailleux, L Eberst, T Bachelot - British journal of cancer, 2021 - nature.com
Brain metastases from breast cancer (BCBM) constitute the second most common cause of
brain metastasis (BM), and the incidence of these frequently lethal lesions is currently …
brain metastasis (BM), and the incidence of these frequently lethal lesions is currently …
Survival in patients with brain metastases: summary report on the updated diagnosis-specific graded prognostic assessment and definition of the eligibility quotient
PURPOSE Conventional wisdom has rendered patients with brain metastases ineligible for
clinical trials for fear that poor survival could mask the benefit of otherwise promising …
clinical trials for fear that poor survival could mask the benefit of otherwise promising …
Summary report on the graded prognostic assessment: an accurate and facile diagnosis-specific tool to estimate survival for patients with brain metastases
Purpose Our group has previously published the Graded Prognostic Assessment (GPA), a
prognostic index for patients with brain metastases. Updates have been published with …
prognostic index for patients with brain metastases. Updates have been published with …
Brain metastases: A Society for Neuro-Oncology (SNO) consensus review on current management and future directions
Brain metastases occur commonly in patients with advanced solid malignancies. Yet, less is
known about brain metastases than cancer-related entities of similar incidence. Advances in …
known about brain metastases than cancer-related entities of similar incidence. Advances in …
Lapatinib plus capecitabine in patients with previously untreated brain metastases from HER2-positive metastatic breast cancer (LANDSCAPE): a single-group phase …
Background Brain metastases occur in 30–50% of patients with metastatic HER2-positive
breast cancer. In the case of diffuse brain metastases, treatment is based on whole brain …
breast cancer. In the case of diffuse brain metastases, treatment is based on whole brain …
Theranostic AGuIX nanoparticles as radiosensitizer: A phase I, dose-escalation study in patients with multiple brain metastases (NANO-RAD trial)
C Verry, S Dufort, J Villa, M Gavard, C Iriart… - Radiotherapy and …, 2021 - Elsevier
Background and purpose Brain metastasis impacts greatly on patients' quality of life and
survival. The phase I NANO-RAD trial assessed the safety and maximum tolerated dose of …
survival. The phase I NANO-RAD trial assessed the safety and maximum tolerated dose of …
Impact of breast cancer molecular subtypes on the incidence, kinetics and prognosis of central nervous system metastases in a large multicentre real-life cohort
Background Metastatic breast cancer (MBC) behaviour differs depending on hormone
receptors (HR) and human epidermal growth factor receptor (HER2) statuses. Methods The …
receptors (HR) and human epidermal growth factor receptor (HER2) statuses. Methods The …
Molecular and cellular mechanisms underlying brain metastasis of breast cancer
M Hosonaga, H Saya, Y Arima - Cancer and Metastasis Reviews, 2020 - Springer
Metastasis of cancer cells to the brain occurs frequently in patients with certain subtypes of
breast cancer. In particular, patients with HER2-positive or triple-negative breast cancer are …
breast cancer. In particular, patients with HER2-positive or triple-negative breast cancer are …