The metabolic properties of cancer cells diverge significantly from those of normal cells.
Energy production in cancer cells is abnormally dependent on aerobic glycolysis. In addition …

Inflammatory immune cells, when activated, display much the same metabolic profile as a
glycolytic tumor cell. This involves a shift in metabolism away from oxidative phosphorylation …

Solid tumors, including the aggressive primary brain cancer glioblastoma multiforme,
develop resistance to cell death, in part as a result of a switch from mitochondrial oxidative …

The unique metabolism of most solid tumours (aerobic glycolysis, ie, Warburg effect) is not
only the basis of diagnosing cancer with metabolic imaging but might also be associated …

Lactic acid is a well known metabolic by-product of intense exercise, particularly under
anaerobic conditions. Lactate is also a key source of energy and an important metabolic …

The unique glycolytic metabolism of most solid tumors, known as the Warburg effect, is
associated with resistance to apoptosis that enables cancer cells to survive. Dichloroacetate …

We reviewed the anti-cancer effects of DCA, an orphan drug long used as an investigational
treatment for various acquired and congenital disorders of mitochondrial intermediary …

Activation of the p53 signaling pathway by DNA‐damaging agents was originally proposed
to result either in cell cycle checkpoint activation to promote survival or in apoptotic cell …

Current drug development in oncology is non-selective as it typically focuses on pathways
essential for the survival of all dividing cells. The unique metabolic profile of cancer, which is …

Metal–organic frameworks (MOFs), network structures wherein metal ions or clusters link
organic ligands into porous materials, are being actively researched as nanoscale drug …