NF-κB signaling has been discovered for nearly 40 years. Initially, NF-κB signaling was
identified as a pivotal pathway in mediating inflammatory responses. However, with …

Ischemic heart disease is the greatest health burden and most frequent cause of death
worldwide. Myocardial ischemia/reperfusion is the pathophysiological substrate of ischemic …

The dysfunction of blood-vessel-lining endothelial cells is a major cause of mortality.
Although endothelial cells, being present in all organs as a single-cell layer, are often …

Autoimmune diseases are associated with a dramatically increased risk of atherosclerotic
cardiovascular disease and its clinical manifestations. The increased risk is consistent with …

Particle-based drug delivery systems have shown promising application potential to treat
human diseases; however, an incomplete understanding of their interactions with vascular …

Vascular endothelial cells form a monolayer in the vascular lumen and act as a selective
barrier to control the permeability between blood and tissues. To maintain homeostasis, the …

The recent and exciting success of anti-inflammatory therapies for ischemic heart disease
(eg atherosclerosis) is hindered by the lack of site-specific and targeted therapeutic …

Blood vessels are lined by a single layer of endothelial cells that provide a barrier between
circulating plasma and the underlying tissue. Permeability of endothelial cells is tightly …

Atherosclerosis (AS) is a severe vascular disease that results in millions of cases of mortality
each year. The development of atherosclerosis is associated with vascular structural lesions …

Atherosclerosis, a chronic inflammatory condition, remains a leading cause of death
globally, necessitating innovative approaches to target pro-atherogenic pathways. Recent …