Sepsis-associated brain injury: underlying mechanisms and potential therapeutic strategies for acute and long-term cognitive impairments

N Sekino, M Selim, A Shehadah - Journal of Neuroinflammation, 2022 - Springer
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to
infection. Sepsis causes cerebral dysfunction in the short and long term and induces …

Sepsis‐induced brain dysfunction: pathogenesis, diagnosis, and treatment

S Pan, Z Lv, R Wang, H Shu, S Yuan… - … medicine and cellular …, 2022 - Wiley Online Library
Dysregulated host response to infection, which cause life‐threatening organ dysfunction,
was defined as sepsis. Sepsis can cause acute and long‐term brain dysfunction, namely …

Fecal microbiota transplantation: a new therapeutic attempt from the gut to the brain

HM Xu, HL Huang, YL Zhou, HL Zhao… - Gastroenterology …, 2021 - Wiley Online Library
Gut dysbacteriosis is closely related to various intestinal and extraintestinal diseases. Fecal
microbiota transplantation (FMT) is a biological therapy that entails transferring the gut …

An Fgr kinase inhibitor attenuates sepsis-associated encephalopathy by ameliorating mitochondrial dysfunction, oxidative stress, and neuroinflammation via the …

Y Liu, H Yang, N Luo, Y Fu, F Qiu, Z Pan, X Li… - Journal of Translational …, 2023 - Springer
Background Sepsis-associated encephalopathy (SAE) is characterized by diffuse brain
dysfunction, long-term cognitive impairment, and increased morbidity and mortality. The …

Neutrophil extracellular traps and organ dysfunction in sepsis

S Kumar, N Payal, VK Srivastava, S Kaushik… - Clinica Chimica …, 2021 - Elsevier
Sepsis is a clinical syndrome resulting from infection followed by inflammation and is one of
the significant causes of mortality worldwide. The underlying reason is the host's …

Polarization of microglia and its therapeutic potential in sepsis

LVG Castro, CF Gonçalves-de-Albuquerque… - International Journal of …, 2022 - mdpi.com
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to
infection, leaving the inflammation process without a proper resolution, leading to tissue …

Effects of hydrogen-rich saline in neuroinflammation and mitochondrial dysfunction in rat model of sepsis-associated encephalopathy

JS Dumbuya, S Li, L Liang, Y Chen, J Du… - Journal of Translational …, 2022 - Springer
Background Sepsis-associated encephalopathy (SAE) is one of the most common types of
sepsis-related organ dysfunction without overt central nervous system (CNS) infection. It is …

The association between the presence and burden of periodic discharges and outcome in septic patients: an observational prospective study

L Ferlini, C Maenhout, IA Crippa, AA Quispe-Cornejo… - Critical Care, 2023 - Springer
Background Sepsis-associated encephalopathy (SAE) is frequent in septic patients.
Electroencephalography (EEG) is very sensitive to detect early epileptic abnormalities, such …

Kynurenic acid and its synthetic derivatives protect against sepsis-associated neutrophil activation and brain mitochondrial dysfunction in rats

MZ Poles, A Nászai, L Gulácsi, BL Czakó… - Frontiers in …, 2021 - frontiersin.org
Background and Aims The systemic host response in sepsis is frequently accompanied by
central nervous system (CNS) dysfunction. Evidence suggests that excessive formation of …

Paediatric sepsis-associated encephalopathy (SAE): a comprehensive review

JS Dumbuya, S Li, L Liang, Q Zeng - Molecular Medicine, 2023 - Springer
Sepsis-associated encephalopathy (SAE) is one of the most common types of organ
dysfunction without overt central nervous system (CNS) infection. It is associated with higher …