New approaches and challenges to targeting the endocannabinoid system
V Di Marzo - Nature Reviews Drug Discovery, 2018 - nature.com
The endocannabinoid signalling system was discovered because receptors in this system
are the targets of compounds present in psychotropic preparations of Cannabis sativa. The …
are the targets of compounds present in psychotropic preparations of Cannabis sativa. The …
Endocannabinoid signaling and synaptic function
Endocannabinoids are key modulators of synaptic function. By activating cannabinoid
receptors expressed in the central nervous system, these lipid messengers can regulate …
receptors expressed in the central nervous system, these lipid messengers can regulate …
Pathophysiology of L-dopa-induced motor and non-motor complications in Parkinson's disease
Involuntary movements, or dyskinesia, represent a debilitating complication of levodopa (L-
dopa) therapy for Parkinson's disease (PD). L-dopa-induced dyskinesia (LID) are ultimately …
dopa) therapy for Parkinson's disease (PD). L-dopa-induced dyskinesia (LID) are ultimately …
Cannabinoid receptors in the central nervous system: their signaling and roles in disease
DA Kendall, GA Yudowski - Frontiers in cellular neuroscience, 2017 - frontiersin.org
The identification and cloning of the two major cannabinoid (CB1 and CB2) receptors
together with the discovery of their endogenous ligands in the late 80s and early 90s …
together with the discovery of their endogenous ligands in the late 80s and early 90s …
Therapeutic potential of β-arrestin-and G protein-biased agonists
Members of the seven-transmembrane receptor (7TMR), or G protein-coupled receptor
(GPCR), superfamily represent some of the most successful targets of modern drug therapy …
(GPCR), superfamily represent some of the most successful targets of modern drug therapy …
It is our turn to get cannabis high: Put cannabinoids in food and health baskets
Cannabis is an annual plant with a long history of use as food, feed, fiber, oil, medicine, and
narcotics. Despite realizing its true value, it has not yet found its true place. Cannabis has …
narcotics. Despite realizing its true value, it has not yet found its true place. Cannabis has …
The endocannabinoid system in anxiety, fear memory and habituation
S Ruehle, AA Rey, F Remmers… - Journal of …, 2012 - journals.sagepub.com
Evidence for the involvement of the endocannabinoid system (ECS) in anxiety and fear has
been accumulated, providing leads for novel therapeutic approaches. In anxiety, a …
been accumulated, providing leads for novel therapeutic approaches. In anxiety, a …
Current evidence of cannabinoid‐based analgesia obtained in preclinical and human experimental settings
J Lötsch, I Weyer‐Menkhoff… - European journal of pain, 2018 - Wiley Online Library
Cannabinoids have a long record of recreational and medical use and become increasingly
approved for pain therapy. This development is based on preclinical and human …
approved for pain therapy. This development is based on preclinical and human …
Type 1 cannabinoid receptor ligands display functional selectivity in a cell culture model of striatal medium spiny projection neurons
Modulation of type 1 cannabinoid receptor (CB 1) activity has been touted as a potential
means of treating addiction, anxiety, depression, and neurodegeneration. Different agonists …
means of treating addiction, anxiety, depression, and neurodegeneration. Different agonists …
SGIP1 in axons prevents internalization of desensitized CB1R and modifies its function
In the central nervous system (CNS), cannabinoid receptor 1 (CB1R) is preferentially
expressed in axons where it has a unique property, namely resistance to agonist-driven …
expressed in axons where it has a unique property, namely resistance to agonist-driven …