The protein folding problem was first articulated as question of how order arose from
disorder in proteins: How did the various native structures of proteins arise from interatomic …

Small-molecule self-assembly is an established route for producing high-surface-area
nanostructures with readily customizable chemistries and precise molecular organization …

Cell migration profoundly influences cellular function, often resulting in adverse effects in
various pathologies including cancer metastasis. Directly assessing and quantifying the …

Self-assembly of small amphiphilic molecules in water can lead to nanostructures of varying
geometries with pristine internal molecular organization. Here we introduce a …

Engineering functional amyloids through a modular genetic strategy represents new
opportunities for creating multifunctional molecular materials with tailored structures and …

Amyloid fibril formation is central to the pathology of many diseases, including
neurodegenerative disorders such as Alzheimer's and Parkinson's disease. Amyloid fibrils …

The amyloid fibrillar form of the protein Tau is involved in a number of neurodegenerative
diseases, also known as tauopathies. In this work, six different fibrillar Tau isoforms were …

The aggregation of transactive response deoxyribonucleic acid (DNA) binding protein of 43
kDa (TDP-43) into ubiquitin-positive inclusions is closely associated with amyotrophic lateral …

Self-assembly of small molecules in water provides a bottom-up strategy to generate highly
ordered nanostructures with dimensions on molecular (< 10 nm) length scales. However …