In autoimmune diseases, recognition of self-antigens presented by major histocompatibility
complex (MHC) molecules elicits unexpected attack of tissue by autoantibodies and/or …

Chromogranin A (ChgA) is an acidic pro-protein found in neuroendocrine organs,
pheochromocytoma chromaffin granules, and tumor cells. Proteolytic processing of ChgA …

Autoimmune attack toward pancreatic β cells causes permanent loss of glucose
homeostasis in type 1 diabetes (T1D). Insulin secretory granules store and secrete insulin …

Autoimmune diabetes is a disease characterized by the selective destruction of insulin-
secreting β-cells of the endocrine pancreas by islet-reactive T cells. Autoimmune disease …

The pancreatic islet microenvironment is highly oxidative, rendering β cells vulnerable to
autoinflammatory insults. Here, we examined the role of islet resident macrophages in the …

There is accumulating evidence that pathogenic T cells in T1D recognize epitopes formed
by post-translational modifications of β-cell antigens, including hybrid insulin peptides …

Biochemical abnormalities in the course of type 1 diabetes (T1D) may cause the
production/activation of various proteins and peptides influencing treatment and causing a …

Thymic presentation of self-antigens is critical for establishing a functional yet self-tolerant T-
cell population. Hybrid peptides formed through transpeptidation within pancreatic β-cell …

Our previous studies have indicated that insulin resistance, hyperglycemia, and
hypertension in aged wild-type (WT) mice can be reversed in mice lacking chromogranin A …

ABSTRACT Type 1 diabetes (T1D) affects a genetically susceptible population that develops
autoreactive T cells attacking insulin-producing pancreatic β cells. Increasingly, neoantigens …