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GPNMB: a potent inducer of immunosuppression in cancer
The immune system is comprised of both innate and adaptive immune cells, which, in the
context of cancer, collectively function to eliminate tumor cells. However, tumors can actively …
context of cancer, collectively function to eliminate tumor cells. However, tumors can actively …
Combination therapy involving HSP90 inhibitors for combating cancer: an overview of clinical and preclinical progress
Y Liu, C Li, H Liu, S Tan - Archives of Pharmacal Research, 2024 - Springer
The molecular chaperone heat shock protein 90 (HSP90) regulates multiple crucial
signalling pathways in cancer by driving the maturation of key signalling components …
signalling pathways in cancer by driving the maturation of key signalling components …
[HTML][HTML] Marine proteins and peptides: Production, biological activities, and potential applications
IPS Fernando, TU Jayawardena… - Food Innovation and …, 2023 - maxapress.com
Marine protein hydrolysates and peptides have grown in popularity due to their biological
activities and robust properties. They are increasingly studied in the functional food …
activities and robust properties. They are increasingly studied in the functional food …
Exploring the synergistic effect of tegafur-syringic acid adduct against breast cancer through DFT computation, spectroscopy, pharmacokinetics and molecular docking …
A Zochedh, K Chandran… - Polycyclic Aromatic …, 2024 - Taylor & Francis
The most prevalent kind of cancer and the main reason for cancer-related deaths in women
is breast cancer. Synergistic drug delivery plays an effective role in the treatment of cancer …
is breast cancer. Synergistic drug delivery plays an effective role in the treatment of cancer …
CCN3/NOV promotes metastasis and tumor progression via GPNMB-induced EGFR activation in triple-negative breast cancer
S Son, H Kim, H Lim, J Lee, K Lee, I Shin - Cell Death & Disease, 2023 - nature.com
Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer.
TNBC patients typically exhibit unfavorable outcomes due to its rapid growth and metastatic …
TNBC patients typically exhibit unfavorable outcomes due to its rapid growth and metastatic …
Investigation of the anti-cancer potential of epoxyazadiradione in neuroblastoma: experimental assays and molecular analysis
S Chandel, A Bhattacharya, A Gautam… - Journal of …, 2024 - Taylor & Francis
Neuroblastoma, the most common childhood solid tumor, originates from primitive
sympathetic nervous system cells. Epoxyazadiradione (EAD) is a limonoid derived from …
sympathetic nervous system cells. Epoxyazadiradione (EAD) is a limonoid derived from …
[PDF][PDF] Computer-aided analysis of biochanin-a as a potential breast cancer drug based on dft, molecular docking, and pharmacokinetic studies
Breast cancer is the most often diagnosed and deadliest type of cancer in the world.
Biochanin A is a naturally available isoflavone with various biological and pharmacological …
Biochanin A is a naturally available isoflavone with various biological and pharmacological …
[HTML][HTML] Heterocyclic compounds as Hsp90 inhibitors: a perspective on anticancer applications
M Ardestani, Z Khorsandi, F Keshavarzipour, S Iravani… - Pharmaceutics, 2022 - mdpi.com
Heat shock proteins (Hsps) have garnered special attention in cancer therapy as molecular
chaperones with regulatory/mediatory effects on folding, maintenance/stability, maturation …
chaperones with regulatory/mediatory effects on folding, maintenance/stability, maturation …
ImmunoPET imaging identifies the optimal timepoint for combination therapy in xenograft models of triple-negative breast cancer
Z Li, E Belitzky, O Blaha, A Cavaliere, SR Katz… - Cancers, 2023 - mdpi.com
Simple Summary Different combination therapies are being investigated for the treatment of
triple-negative breast cancer (TNBC). Dasatinib is one such drug that targets the Src …
triple-negative breast cancer (TNBC). Dasatinib is one such drug that targets the Src …
Truncated GPNMB, a microglial transmembrane protein, serves as a scavenger receptor for oligomeric β‐amyloid peptide1‐42 in primary type 1 microglia
K Kawahara, T Hasegawa, N Hasegawa… - Journal of …, 2024 - Wiley Online Library
Glycoprotein non‐metastatic melanoma protein B (GPNMB) is up‐regulated in one subtype
of microglia (MG) surrounding senile plaque depositions of amyloid‐beta (Aβ) peptides …
of microglia (MG) surrounding senile plaque depositions of amyloid‐beta (Aβ) peptides …