GPNMB: a potent inducer of immunosuppression in cancer

AM Lazaratos, MG Annis, PM Siegel - Oncogene, 2022 - nature.com
The immune system is comprised of both innate and adaptive immune cells, which, in the
context of cancer, collectively function to eliminate tumor cells. However, tumors can actively …

Combination therapy involving HSP90 inhibitors for combating cancer: an overview of clinical and preclinical progress

Y Liu, C Li, H Liu, S Tan - Archives of Pharmacal Research, 2024 - Springer
The molecular chaperone heat shock protein 90 (HSP90) regulates multiple crucial
signalling pathways in cancer by driving the maturation of key signalling components …

[HTML][HTML] Marine proteins and peptides: Production, biological activities, and potential applications

IPS Fernando, TU Jayawardena… - Food Innovation and …, 2023 - maxapress.com
Marine protein hydrolysates and peptides have grown in popularity due to their biological
activities and robust properties. They are increasingly studied in the functional food …

Exploring the synergistic effect of tegafur-syringic acid adduct against breast cancer through DFT computation, spectroscopy, pharmacokinetics and molecular docking …

A Zochedh, K Chandran… - Polycyclic Aromatic …, 2024 - Taylor & Francis
The most prevalent kind of cancer and the main reason for cancer-related deaths in women
is breast cancer. Synergistic drug delivery plays an effective role in the treatment of cancer …

CCN3/NOV promotes metastasis and tumor progression via GPNMB-induced EGFR activation in triple-negative breast cancer

S Son, H Kim, H Lim, J Lee, K Lee, I Shin - Cell Death & Disease, 2023 - nature.com
Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer.
TNBC patients typically exhibit unfavorable outcomes due to its rapid growth and metastatic …

Investigation of the anti-cancer potential of epoxyazadiradione in neuroblastoma: experimental assays and molecular analysis

S Chandel, A Bhattacharya, A Gautam… - Journal of …, 2024 - Taylor & Francis
Neuroblastoma, the most common childhood solid tumor, originates from primitive
sympathetic nervous system cells. Epoxyazadiradione (EAD) is a limonoid derived from …

[PDF][PDF] Computer-aided analysis of biochanin-a as a potential breast cancer drug based on dft, molecular docking, and pharmacokinetic studies

M Priya, A Zochedh, K Chandran… - Letters in Applied …, 2022 - nanobioletters.com
Breast cancer is the most often diagnosed and deadliest type of cancer in the world.
Biochanin A is a naturally available isoflavone with various biological and pharmacological …

[HTML][HTML] Heterocyclic compounds as Hsp90 inhibitors: a perspective on anticancer applications

M Ardestani, Z Khorsandi, F Keshavarzipour, S Iravani… - Pharmaceutics, 2022 - mdpi.com
Heat shock proteins (Hsps) have garnered special attention in cancer therapy as molecular
chaperones with regulatory/mediatory effects on folding, maintenance/stability, maturation …

ImmunoPET imaging identifies the optimal timepoint for combination therapy in xenograft models of triple-negative breast cancer

Z Li, E Belitzky, O Blaha, A Cavaliere, SR Katz… - Cancers, 2023 - mdpi.com
Simple Summary Different combination therapies are being investigated for the treatment of
triple-negative breast cancer (TNBC). Dasatinib is one such drug that targets the Src …

Truncated GPNMB, a microglial transmembrane protein, serves as a scavenger receptor for oligomeric β‐amyloid peptide1‐42 in primary type 1 microglia

K Kawahara, T Hasegawa, N Hasegawa… - Journal of …, 2024 - Wiley Online Library
Glycoprotein non‐metastatic melanoma protein B (GPNMB) is up‐regulated in one subtype
of microglia (MG) surrounding senile plaque depositions of amyloid‐beta (Aβ) peptides …