[HTML][HTML] It's complicated: The relationship between sleep and Alzheimer's disease in humans
BP Lucey - Neurobiology of disease, 2020 - Elsevier
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by an
asymptomatic period of amyloid-β (Aβ) deposition as insoluble extracellular plaque …
asymptomatic period of amyloid-β (Aβ) deposition as insoluble extracellular plaque …
PET imaging of neural activity, β-amyloid, and tau in normal brain aging
K Zhang, H Mizuma, X Zhang, K Takahashi… - European Journal of …, 2021 - Springer
Normal brain aging is commonly associated with neural activity alteration, β-amyloid (Aβ)
deposition, and tau aggregation, driving a progressive cognitive decline in normal elderly …
deposition, and tau aggregation, driving a progressive cognitive decline in normal elderly …
Suvorexant acutely decreases tau phosphorylation and Aβ in the human CNS
Objective In Alzheimer's disease, hyperphosphorylated tau is associated with formation of
insoluble paired helical filaments that aggregate as neurofibrillary tau tangles and are …
insoluble paired helical filaments that aggregate as neurofibrillary tau tangles and are …
[HTML][HTML] Impact of sleep disturbances on neurodegeneration: Insight from studies in animal models
JE Owen, SC Veasey - Neurobiology of disease, 2020 - Elsevier
Chronic short sleep or extended wake periods are commonly observed in most
industrialized countries. Previously neurobehavioral impairment following sleep loss was …
industrialized countries. Previously neurobehavioral impairment following sleep loss was …
The sleep side of aging and Alzheimer's disease
As we age, sleep patterns undergo significant modifications in micro and macrostructure,
worsening cognition and quality of life. These are associated with remarkable brain …
worsening cognition and quality of life. These are associated with remarkable brain …
Hypocretin/orexin, sleep and Alzheimer's disease
Y Dauvilliers - The Orexin System. Basic Science and Role in Sleep …, 2021 - karger.com
Advances in translational research provide key opportunities to explore the physiological
and pathological effects of sleep in different neurodegenerative diseases. Recent findings …
and pathological effects of sleep in different neurodegenerative diseases. Recent findings …
Plasma Aβ and neurofilament light chain are associated with cognitive and physical function decline in non-dementia older adults
Background Cognition is closely associated with physical function. Although high brain
amyloid-β (Aβ) deposition and neurofilament light chain (NfL) are associated with cognitive …
amyloid-β (Aβ) deposition and neurofilament light chain (NfL) are associated with cognitive …
Associations of sleep disorders with all-cause MCI/dementia and different types of dementia–clinical evidence, potential pathomechanisms and treatment options: A …
G Mayer, H Frohnhofen, M Jokisch… - Frontiers in …, 2024 - frontiersin.org
Due to worldwide demographic change, the number of older persons in the population is
increasing. Aging is accompanied by changes of sleep structure, deposition of beta-amyloid …
increasing. Aging is accompanied by changes of sleep structure, deposition of beta-amyloid …
International union of basic and clinical pharmacology CXIV: Orexin receptor function, nomenclature and pharmacology
The orexin system consists of the peptide transmitters orexin-A and-B and the G protein-
coupled orexin receptors OX 1 and OX 2. Orexin receptors are capable of coupling to all four …
coupled orexin receptors OX 1 and OX 2. Orexin receptors are capable of coupling to all four …
Focus on the complex interconnection between cancer, narcolepsy and other neurodegenerative diseases: a possible case of orexin-dependent inverse comorbidity
Simple Summary This narrative review first describes from several points of view the
complex interrelationship between cancer and neurodegeneration, with special attention to …
complex interrelationship between cancer and neurodegeneration, with special attention to …