O-linked β-dN-acetylglucosamine (O-GlcNAc) is an important post-translational modification
of serine or threonine residues on thousands of proteins in the nucleus and cytoplasm of all …

O-linked β-DN-acetylglucosamine (O-GlcNAc), as a posttranslational modification (PTM), is
a reversible reaction that attaches β-N-GlcNAc to Ser/Thr residues on specific proteins by O …

Intron detention in precursor RNAs serves to regulate expression of a substantial fraction of
genes in eukaryotic genomes. How detained intron (DI) splicing is controlled is poorly …

The oncoprotein transcription factor MYC is a major driver of malignancy and a highly
validated but challenging target for the development of anticancer therapies. Novel …

O-GlcNAcylation is a post-translational modification occurring on serine/threonine residues
of nuclear and cytoplasmic proteins, mediated by the enzymes OGT and OGA which …

Hepatocellular carcinoma (HCC) is a highly heterogeneous, multigene-driven malignant
tumor. Long chain acyl-CoA synthetase 4 (ACSL4), an enzyme has pivotal roles in …

Background Hepatocellular carcinoma (HCC) remains one of the most common malignant
neoplasms. Lysophosphatidylcholine acyltransferase 1 (LPCAT1) plays a key role in the …

After androgen deprivation, prostate cancer frequently becomes castration resistant (CRPC),
with intratumoral androgen production from extragonadal precursors that activate the …

Aims Drivers of the drug tolerant proliferative persister (DTPP) state have not been well
investigated. Histone H3 lysine-4 trimethylation (H3K4me3), an active histone mark, might …

The incidence of thyroid cancer is growing rapidly during the past decades worldwide.
Although most thyroid tumors are curable, some patients diagnosed with distant metastases …