Repositioning TH cell polarization from single cytokines to complex help
When helper T (TH) cell polarization was initially described three decades ago, the TH cell
universe grew dramatically. New subsets were described based on their expression of few …
universe grew dramatically. New subsets were described based on their expression of few …
Harnessing innate immunity in cancer therapy
New therapies that promote antitumour immunity have been recently developed. Most of
these immunomodulatory approaches have focused on enhancing T-cell responses, either …
these immunomodulatory approaches have focused on enhancing T-cell responses, either …
Predictors of anti-TNF treatment failure in anti-TNF-naive patients with active luminal Crohn's disease: a prospective, multicentre, cohort study
Background Anti-TNF drugs are effective treatments for the management of Crohn's disease
but treatment failure is common. We aimed to identify clinical and pharmacokinetic factors …
but treatment failure is common. We aimed to identify clinical and pharmacokinetic factors …
Balancing natural killer cell activation through paired receptors
Natural killer (NK) cells are innate lymphocytes that are crucial for the control of infections
and malignancies. NK cells express a variety of inhibitory and activating receptors that …
and malignancies. NK cells express a variety of inhibitory and activating receptors that …
Why science needs philosophy
L Laplane, P Mantovani, R Adolphs… - Proceedings of the …, 2019 - National Acad Sciences
A knowledge of the historic and philosophical background gives that kind of independence
from prejudices of his generation from which most scientists are suffering. This …
from prejudices of his generation from which most scientists are suffering. This …
Effect of tumor cells and tumor microenvironment on NK‐cell function
The ability of tumors to manage an immune‐mediated attack has been recently included in
the “next generation” of cancer hallmarks. In solid tumors, the microenvironment that is …
the “next generation” of cancer hallmarks. In solid tumors, the microenvironment that is …
Immunity by equilibrium
G Eberl - Nature Reviews Immunology, 2016 - nature.com
The classical model of immunity posits that the immune system reacts to pathogens and
injury and restores homeostasis. Indeed, a century of research has uncovered the means …
injury and restores homeostasis. Indeed, a century of research has uncovered the means …
Natural killer cell education and the response to infection and cancer therapy: stay tuned
The functional capacities of natural killer (NK) cells differ within and between individuals,
reflecting considerable genetic variation.'Licensing/arming','disarming', and 'tuning'are …
reflecting considerable genetic variation.'Licensing/arming','disarming', and 'tuning'are …
Therapeutic potential and challenges of natural killer cells in treatment of solid tumors
A Gras Navarro, AT Björklund, M Chekenya - Frontiers in immunology, 2015 - frontiersin.org
Natural killer (NK) cells are innate lymphoid cells that hold tremendous potential for effective
immunotherapy for a broad range of cancers. Due to the mode of NK cell killing, requiring …
immunotherapy for a broad range of cancers. Due to the mode of NK cell killing, requiring …
CD8+ T cells and NK cells: parallel and complementary soldiers of immunotherapy
J Rosenberg, J Huang - Current opinion in chemical engineering, 2018 - Elsevier
Highlights•CD8+ T cells and NK cells are both cytotoxic cells with engineering potential.•NK
cells are comparable to CD8+ T cells but far less understood.•Cancer immunotherapies …
cells are comparable to CD8+ T cells but far less understood.•Cancer immunotherapies …