Review on strategies and technologies for exosome isolation and purification

J Chen, P Li, T Zhang, Z Xu, X Huang… - … in bioengineering and …, 2022 - frontiersin.org
Exosomes, a nano-sized subtype of extracellular vesicles secreted from almost all living
cells, are capable of transferring cell-specific constituents of the source cell to the recipient …

The updated role of exosomal proteins in the diagnosis, prognosis, and treatment of cancer

X Wang, J Huang, W Chen, G Li, Z Li… - Experimental & molecular …, 2022 - nature.com
Exosomes are vesicles encompassed by a lipid bilayer that are released by various living
cells. Exosomal proteins are encapsulated within the membrane or embedded on the …

Aptamer-based detection of circulating targets for precision medicine

L Wu, Y Wang, X Xu, Y Liu, B Lin, M Zhang… - Chemical …, 2021 - ACS Publications
The past decade has witnessed ongoing progress in precision medicine to improve human
health. As an emerging diagnostic technique, liquid biopsy can provide real-time …

Application of exosomes as liquid biopsy in clinical diagnosis

B Zhou, K Xu, X Zheng, T Chen, J Wang… - Signal transduction and …, 2020 - nature.com
Liquid biopsy refers to the sampling and molecular analysis of the biofluids of circulating
tumor cells, extracellular vesicles, nucleic acids, and so forth. Exosomes are small …

Exosomal miRNA-mediated intercellular communications and immunomodulatory effects in tumor microenvironments

HM Nail, CC Chiu, CH Leung, MMM Ahmed… - Journal of biomedical …, 2023 - Springer
Extracellular communication, in other words, crosstalk between cells, has a pivotal role in
the survival of an organism. This communication occurs by different methods, one of which is …

Potential clinical utility of liquid biopsies in ovarian cancer

JW Zhu, P Charkhchi, MR Akbari - Molecular cancer, 2022 - Springer
Background Ovarian cancer (OC) is the most lethal gynecologic malignancy worldwide. One
of the main challenges in the management of OC is the late clinical presentation of disease …

Extracellular vesicles in cancer: cell-to-cell mediators of metastasis

A Becker, BK Thakur, JM Weiss, HS Kim, H Peinado… - Cancer cell, 2016 - cell.com
Tumor-secreted extracellular vesicles (EVs) are critical mediators of intercellular
communication between tumor cells and stromal cells in local and distant …

The biology and function of exosomes in cancer

R Kalluri - The Journal of clinical investigation, 2016 - jci.org
Humans circulate quadrillions of exosomes at all times. Exosomes are a class of
extracellular vesicles released by all cells, with a size range of 40–150 nm and a lipid …

Glypican-1 identifies cancer exosomes and detects early pancreatic cancer

SA Melo, LB Luecke, C Kahlert, AF Fernandez… - Nature, 2015 - nature.com
Exosomes are lipid-bilayer-enclosed extracellular vesicles that contain proteins and nucleic
acids. They are secreted by all cells and circulate in the blood. Specific detection and …

Extracellular vesicles: composition, biological relevance, and methods of study

MŁP Zaborowski, L Balaj, XO Breakefield, CP Lai - Bioscience, 2015 - academic.oup.com
The release of extracellular vesicles (EVs), including exosomes and microvesicles, is a
phenomenon shared by many cell types as a means of communicating with other cells and …