INTRODUCTION Brain disorders may exhibit shared symptoms and substantial
epidemiological comorbidity, inciting debate about their etiologic overlap. However, detailed …

We propose a taxonomy of psychopathology based on patterns of shared causal influences
identified in a review of multivariate behavior genetic studies that distinguish genetic and …

INTRODUCTION: Brain disorders may exhibit shared symptoms and substantial epidemio-
logical comorbidity, inciting debate about their etiologic overlap. However, detailed study of …

We introduce multi-trait analysis of GWAS (MTAG), a method for joint analysis of summary
statistics from genome-wide association studies (GWAS) of different traits, possibly from …

Neuroticism is an important risk factor for psychiatric traits, including depression, anxiety,,
and schizophrenia,–. At the time of analysis, previous genome-wide association studies …

Polygenic indexes (PGIs) are DNA-based predictors. Their value for research in many
scientific disciplines is growing rapidly. As a resource for researchers, we used a consistent …

We conducted genome-wide association analyses of over 250,000 participants of European
(EUR) and African (AFR) ancestry from the Million Veteran Program using electronic health …

We develop a Bayesian mixed linear model that simultaneously estimates single-nucleotide
polymorphism (SNP)-based heritability, polygenicity (proportion of SNPs with nonzero …

Very few genetic variants have been associated with depression and neuroticism, likely
because of limitations on sample size in previous studies. Subjective well-being, a …

Personality is influenced by genetic and environmental factors and associated with mental
health. However, the underlying genetic determinants are largely unknown. We identified six …