Simple Summary Overexpression of ABCB1 has been identified in a wide range of multidrug-
resistant cancers. ABCB1 can become upregulated in many ways, and understanding these …

Urine represents an unlimited source of patient‐specific kidney cells that can be harvested
noninvasively. Urine derived podocytes and proximal tubule cells have been used to study …

Despite the increasing incidence of kidney-related diseases, we are still far from
understanding the underlying mechanisms of these diseases and their progression. This …

Nephropathic cystinosis is a severe monogenic kidney disorder caused by mutations in
CTNS, encoding the lysosomal transporter cystinosin, resulting in lysosomal cystine …

The ATP-binding cassette transport proteins (ABC transporters) represent important
determinants of drug excretion. Protective or excretory tissues where these transporters …

Epithelial cells exfoliated in human urine can include cells anywhere from the urinary tract
and kidneys; however, podocytes and proximal tubular epithelial cells (PTECs) are by far the …

The blood-brain barrier (BBB) is a critical interface separating the central nervous system
from the peripheral circulation, ensuring brain homeostasis and function. Recent research …

Background: Calcineurin inhibitors (CNIs) are the primary immunosuppressive drugs used
in solid organ transplantation but are associated with the development of histological lesions …

Nephropathic cystinosis is a rare and severe disease caused by disruptions in the CTNS
gene. Cystinosis is characterized by lysosomal cystine accumulation, vesicle trafficking …

Nephropathic cystinosis is a severe monogenetic kidney disorder caused by mutations in
CTNS, encoding the lysosomal transporter cystinosin, resulting in lysosomal cystine …