Structure-based virtual screening (SBVS), also known as molecular docking, has been
increasingly applied to discover small-molecule ligands based on the protein structures in …

Deregulated NF-κB signalling is implicated in the pathogenesis of numerous human
inflammatory disorders and malignancies. Consequently, the NF-κB pathway has attracted …

Background: Indicaxanthin, a betaxanthin belonging to the betalain class of compounds, has
been recently demonstrated to exert significant antiproliferative effects inducing apoptosis of …

Background Abietic acid (AA) is one of the terpenoids, which are multifunctional natural
compounds. It has been reported that AA possesses favorable therapeutic effects on …

Inhibitor of nuclear factor kappa-B kinase subunit beta (IKKβ) is a key regulator of the
cannonical NF-κB pathway. IKKβ has been validated as a drug target for pathological …

In Alzheimer's disease (AD), neuroinflammation is detrimental in causing
neurodegeneration. In the central nervous system, inhibitor of nuclear factor kappa B kinase …

Glioblastoma is the most commonly occurring and most lethal primary brain tumor.
Treatment options are limited in number and therapeutic development remains a major …

Deregulation of NF-κB plays an important role in various diseases by controlling cell growth,
inflammation, the immune response, and cytokine production. Although many NF-κB …

Protein kinases represent one of the most successful target classes for the development of
new medicines. Because of their key roles in cellular signalling, kinases are stringently …

In this account, we describe our research on a Lewis acid-catalyzed insertion reaction of α-
diazo esters into a carbon–carbon or carbon–halogen bond. Indium catalysts mediated not …