Antibiotic resistance is a major global health challenge and, worryingly, several key Gram
negative pathogens can become resistant to most currently available antibiotics. Polymyxins …

Bacterial biofilms are associated with a wide range of infections, from those related to
exogenous devices, such as catheters or prosthetic joints, to chronic tissue infections such …

Background The β-lactamase inhibitor relebactam can restore imipenem activity against
imipenem-nonsusceptible gram-negative pathogens. We evaluated imipenem/relebactam …

Background: Infections caused by multi-drug-resistant Gram-negative bacteria, particularly
Acinetobacter baumannii, Pseudomonas aeruginosa and Klebsiella pneumoniae, that …

One or more of the authors of this paper have disclosed potential or pertinent conflicts of
interest, which may include receipt of payment, either direct or indirect, institutional support …

Background: The superiority of combination therapy for carbapenem-resistant Gram-
negative bacilli (CR-GNB) remains controversial. In vitro models may predict the efficacy of …

The polymyxins, colistin (also known as polymyxin E) and polymyxin B, have a unique and
interesting history. Originally introduced in the 1950s for the treatment of infections due to …

Pseudomonas aeruginosa biofilm-related infections are difficult to treat with antibiotics.
Along the different layers of the biofilm, the P. aeruginosa population is heterogeneous …

Infections caused by multi-drug resistant (MDR) bacterial pathogens are a leading cause of
mortality and morbidity across the world. Indiscriminate use of broad-spectrum antibiotics …

Covering: 1947-early 2017, particularly from 2005-early 2017 The rise of bacterial
pathogens with acquired resistance to almost all available antibiotics is becoming a serious …