Amino acid metabolism is a critical regulator of the immune response, and its modulating
becomes a promising approach in various forms of immunotherapy. Insufficient …

Arginase is a key hydrolase in the urea cycle that hydrolyses L-arginine to urea and L-
ornithine. Increasing number of studies in recent years demonstrate that two mammalian …

Metalloenzymes are central to a wide range of essential biological activities, including
nucleic acid modification, protein degradation, and many others. The role of metalloenzymes …

The role of redox molecules, such as NO and ROS, as key mediators of immunity has
recently garnered renewed interest and appreciation. To regulate immune responses, these …

Arginase, a binuclear manganese metalloenzyme in the urea, catalyzes the hydrolysis of L-
arginine to urea and L-ornithine. Both isoforms, arginase 1 and arginase 2 perform …

Arginase is a widely known enzyme of the urea cycle that catalyzes the hydrolysis of L-
arginine to L-ornithine and urea. The action of arginase goes beyond the boundaries of …

Isothermal titration calorimetry (ITC) is a biophysical technique for measuring the formation
and dissociation of molecular complexes and has become an invaluable tool in many …

Background—Endothelial dysfunction plays an important role in the early development of
atherosclerosis and vascular complications in type 2 diabetes mellitus. Increased …

Arginase is a ubiquitous enzyme in the urea cycle (UC) that hydrolyzes L‐arginine to urea
and L‐ornithine. Two mammalian arginase isoforms, arginase1 (ARG1) and arginase2 …

The overexpression of two arginase (ARG) isoforms, ARG1 and ARG2, contributes to the
onset of numerous disorders, including cardiovascular and immune-mediated diseases, as …