The evolution of fungicide resistance

JA Lucas, NJ Hawkins, BA Fraaije - Advances in applied microbiology, 2015 - Elsevier
Fungicides are widely used in developed agricultural systems to control disease and
safeguard crop yield and quality. Over time, however, resistance to many of the most …

Azole fungicides–understanding resistance mechanisms in agricultural fungal pathogens

CL Price, JE Parker, AGS Warrilow… - Pest management …, 2015 - Wiley Online Library
Plant fungal pathogens can have devastating effects on a wide range of crops, including
cereals and fruit (such as wheat and grapes), causing losses in crop yield, which are costly …

Advances in understanding molecular mechanisms of fungicide resistance and molecular detection of resistant genotypes in phytopathogenic fungi

Z Ma, TJ Michailides - Crop Protection, 2005 - Elsevier
Although fungicide treatments are a key component in the integrated management of many
plant diseases, the appearance of resistance has become an important factor in limiting the …

Update on mechanisms of azole resistance in Mycosphaerella graminicola and implications for future control

HJ Cools, BA Fraaije - Pest management science, 2013 - Wiley Online Library
This review summarises recent investigations into the molecular mechanisms responsible
for the decline in sensitivity to azole (imidazole and triazole) fungicides in European …

Overexpression of the sterol 14α‐demethylase gene (MgCYP51) in Mycosphaerella graminicola isolates confers a novel azole fungicide sensitivity phenotype

HJ Cools, C Bayon, S Atkins, JA Lucas… - Pest management …, 2012 - Wiley Online Library
BACKGROUND: The recent evolution towards resistance to azole fungicides in European
populations of the wheat pathogen Mycosphaerella graminicola has been caused by the …

Impact of fungal drug transporters on fungicide sensitivity, multidrug resistance and virulence

MA De Waard, AC Andrade, K Hayashi… - Pest Management …, 2006 - Wiley Online Library
Drug transporters are membrane proteins that provide protection for organisms against
natural toxic products and fungicides. In plant pathogens, drug transporters function in …

Overexpression of the 14α-Demethylase Target Gene (CYP51) Mediates Fungicide Resistance in Blumeriella jaapii

Z Ma, TJ Proffer, JL Jacobs… - Applied and …, 2006 - Am Soc Microbiol
Sterol demethylation inhibitor (DMI) fungicides are widely used to control fungi pathogenic to
humans and plants. Resistance to DMIs is mediated either through alterations in the …

In Vivo Characterization of the Drug Resistance Profile of the Major ABC Transporters and Other Components of the Yeast Pleiotropic Drug Resistance Network

M Kolaczkowski, A Kolaczkowska… - Microbial drug …, 1998 - liebertpub.com
Multidrug resistance (MDR) mediated by broad specificity transporters is one of the most
important strategies used by pathogens, including cancer cells, to evade chemotherapy. In …

Mechanism of Fusarium graminearum Resistance to Ergosterol Biosynthesis Inhibitors: G443S Substitution of the Drug Target FgCYP51A

H Zhao, X Tao, W Song, H Xu, M Li, Y Cai… - Journal of agricultural …, 2022 - ACS Publications
Fusarium head blight (FHB), caused by the Fusarium graminearum species complex, is a
devastating fungal disease resulting in substantial yield and quality losses. Ergosterol …

Mycosphaerella graminicola: from genomics to disease control

ES Orton, S Deller, JKM Brown - Molecular plant pathology, 2011 - Wiley Online Library
This Mycosphaerella graminicola pathogen profile covers recent advances in the knowledge
of this ascomycete fungus and of the disease it causes, septoria tritici blotch of wheat …