From antibacterial to antibiofilm targeting: an emerging paradigm shift in the development of quaternary ammonium compounds (QACs)

EA Saverina, NA Frolov, OA Kamanina… - ACS Infectious …, 2023 - ACS Publications
In a previous development stage, mostly individual antibacterial activity was a target in the
optimization of biologically active compounds and antiseptic agents. Although this targeting …

Antibacterial quaternary ammonium agents: Chemical diversity and biological mechanism

W Dan, J Gao, X Qi, J Wang, J Dai - European journal of medicinal …, 2022 - Elsevier
Bacterial infections have seriously threatened public health especially with the increasing
resistance and the cliff-like decline of the number of newly approved antibacterial agents …

Natural and synthetic halogenated amino acids—Structural and bioactive features in antimicrobial peptides and peptidomimetics

M Mardirossian, M Rubini, MFA Adamo, M Scocchi… - Molecules, 2021 - mdpi.com
The 3D structure and surface characteristics of proteins and peptides are crucial for
interactions with receptors or ligands and can be modified to some extent to modulate their …

Ruthenium (II) complexes targeting membrane as biofilm disruptors and resistance breakers in Staphylococcus aureus bacteria

L Wang, L Liu, X Wang, Y Tan, X Duan, C Zhang… - European Journal of …, 2022 - Elsevier
The development of ruthenium-based complexes or antimicrobial peptides are identified as
a promising strategy for combating drug-resistant bacteria. In this work, four biphenyl-based …

1, 2, 4-Triazole derivatives as novel and potent antifungal agents: Design, synthesis and biological evaluation

S Sadeghian, L Emami, A Mojaddami, Z Faghih… - Journal of Molecular …, 2023 - Elsevier
Fungal infections are still threatening human health due to resistance to existing drugs,
therefore, the design and development of novel antifungal agents is to be necessary and …

[HTML][HTML] Exploring the efficacy of peptides and mimics against Influenza A Virus, Adenovirus, and murine norovirus

UL Urmi, AK Vijay, MDP Willcox, S Attard… - International Journal of …, 2024 - mdpi.com
The ongoing battle against viral pandemics continues, with the possibility of future
outbreaks. The search for effective antiviral compounds that can combat a diverse range of …

Aryloxy Alkyl theophylline derivatives as antifungal agents: design, synthesis, biological evaluation and computational studies

Z Faghih, L Emami, K Zomoridian, R Sabet… - …, 2022 - Wiley Online Library
Infectious diseases are still one of the leading causes of death and disability in human
society. Synthetic antimicrobial agents have recently emerged as promising candidates …

Bioinspired polydopamine coatings facilitate attachment of antimicrobial peptidomimetics with broad-spectrum antibacterial activity

K Browne, R Kuppusamy, R Chen… - International journal of …, 2022 - mdpi.com
The prevention and treatment of biofilm-mediated infections remains an unmet clinical need
for medical devices. With the increasing prevalence of antibiotic-resistant infections, it is …

Cholic acid-based antimicrobial peptide mimics as antibacterial agents

J Wu, TT Yu, R Kuppusamy, MM Hassan… - International Journal of …, 2022 - mdpi.com
There is a significant and urgent need for the development of novel antibacterial agents to
tackle the increasing incidence of antibiotic resistance. Cholic acid-based small molecular …

Polyphenylglyoxamide-based amphiphilic small molecular peptidomimetics as antibacterial agents with anti-biofilm activity

TT Yu, R Kuppusamy, M Yasir, MM Hassan… - International Journal of …, 2021 - mdpi.com
The rapid emergence of drug-resistant bacteria is a major global health concern.
Antimicrobial peptides (AMPs) and peptidomimetics have arisen as a new class of …