Galectins are a family of carbohydrate-binding proteins with an affinity for β-galactosides.
Galectin-1 (Gal-1) is differentially expressed by various normal and pathological tissues and …

Purpose The present review aims to emphasize that malignant gliomas are characterized by
the diffuse invasion of distant brain tissue by a myriad of single migrating cells that exhibit …

The galectins are a family of proteins that are distributed widely in all living organisms. All of
them share galactose-specificity. At present, 14 members of the family are characterized in …

Galectins belong to a family of carbohydrate-binding proteins with an affinity for β-
galactosides. Galectin-1 is differentially expressed by various normal and pathologic tissues …

Human galectin-1 is a potent multifunctional effector that participates in specific protein–
carbohydrate and protein–protein (lipid) interactions. By determining its X-ray structure, we …

An intact immune system is essential to prevent the development and progression of
neoplastic cells in a process termed immune surveillance. During this process the innate …

Galectins are a family of structurally related carbohydrate-binding proteins, which are
defined by their affinity for poly-N-acetyllactosamine-enriched glycoconjugates and …

Abstract Galectin-1 (Gal-1), a homodimeric prototype of the galectins with a single
carbohydrate-recognition domain, was recently identified as being overexpressed in tumor …

Evasion of immune surveillance is an accepted hallmark of tumor progression. The
production of immune suppressive mediators by tumor cells is one of the major mechanisms …

Galectins are an endogenous family of β-galactoside-binding proteins that play complex and
multifaceted roles at various stages of cancer progression, including modulation of tumor …