Network-based in silico drug efficacy screening
The increasing cost of drug development together with a significant drop in the number of
new drug approvals raises the need for innovative approaches for target identification and …
new drug approvals raises the need for innovative approaches for target identification and …
[HTML][HTML] Underlying genetic architecture of resistance to mastitis in dairy cattle: A systematic review and gene prioritization analysis of genome-wide association …
Mastitis, the most frequent disease in dairy cattle. Resistance to mastitis is a complex,
polygenic trait controlled by several genes, each with small effects. Genome-wide …
polygenic trait controlled by several genes, each with small effects. Genome-wide …
Computational approaches for prioritizing candidate disease genes based on PPI networks
With the continuing development and improvement of genome-wide techniques, a great
number of candidate genes are discovered. How to identify the most likely disease genes …
number of candidate genes are discovered. How to identify the most likely disease genes …
Genome-wide association study to identify genomic regions and positional candidate genes associated with male fertility in beef cattle
Fertility plays a key role in the success of calf production, but there is evidence that
reproductive efficiency in beef cattle has decreased during the past half-century worldwide …
reproductive efficiency in beef cattle has decreased during the past half-century worldwide …
Combined GWAS and 'guilt by association'-based prioritization analysis identifies functional candidate genes for body size in sheep
Background Body size in sheep is an important indicator of productivity, growth and health
as well as of environmental adaptation. It is a composite quantitative trait that has been …
as well as of environmental adaptation. It is a composite quantitative trait that has been …
Gene prioritization, communality analysis, networking and metabolic integrated pathway to better understand breast cancer pathogenesis
Consensus strategy was proved to be highly efficient in the recognition of gene-disease
association. Therefore, the main objective of this study was to apply theoretical approaches …
association. Therefore, the main objective of this study was to apply theoretical approaches …
[HTML][HTML] Genetic foundations of Nellore traits: a gene prioritization and Functional Analyses of Genome-Wide Association Study results
The main goal of this study was to pinpoint functional candidate genes associated with
multiple economically important traits in Nellore cattle. After quality control, 1830 genomic …
multiple economically important traits in Nellore cattle. After quality control, 1830 genomic …
GUILDify v2. 0: A tool to identify molecular networks underlying human diseases, their comorbidities and their druggable targets
The genetic basis of complex diseases involves alterations on multiple genes. Unraveling
the interplay between these genetic factors is key to the discovery of new biomarkers and …
the interplay between these genetic factors is key to the discovery of new biomarkers and …
Determination of shared genetic etiology and possible causal relations between tobacco smoking and depression
BackgroundsCigarette smoking is strongly associated with major depressive disorder
(MDD). However, any genetic etiology of such comorbidity and causal relations is poorly …
(MDD). However, any genetic etiology of such comorbidity and causal relations is poorly …
Prioritizing target-disease associations with novel safety and efficacy scoring methods
Biological target (commonly genes or proteins) identification is still largely a manual
process, where experts manually try to collect and combine information from hundreds of …
process, where experts manually try to collect and combine information from hundreds of …