The many important facets of T-cell repertoire diversity
J Nikolich-Žugich, MK Slifka, I Messaoudi - Nature Reviews …, 2004 - nature.com
In the thymus, a diverse and polymorphic T-cell repertoire is generated by random
recombination of discrete T-cell receptor (TCR)-αβ gene segments. This repertoire is then …
recombination of discrete T-cell receptor (TCR)-αβ gene segments. This repertoire is then …
T cell dynamics in HIV-1 infection
DC Douek, LJ Picker, RA Koup - Annual review of immunology, 2003 - annualreviews.org
▪ Abstract In the absence of antiretroviral treatment, HIV-1 establishes a chronic, progressive
infection of the human immune system that invariably, over the course of years, leads to its …
infection of the human immune system that invariably, over the course of years, leads to its …
Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase
Y Minokoshi, YB Kim, OD Peroni, LGD Fryer, C Müller… - Nature, 2002 - nature.com
Leptin is a hormone secreted by adipocytes that plays a pivotal role in regulating food
intake, energy expenditure and neuroendocrine function. Leptin stimulates the oxidation of …
intake, energy expenditure and neuroendocrine function. Leptin stimulates the oxidation of …
HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cells
Establishing a CD8+ T cell–mediated immune correlate of protection in HIV disease is
crucial to the development of vaccines designed to generate cell-mediated immunity …
crucial to the development of vaccines designed to generate cell-mediated immunity …
Superoxide dismutase as a target for the selective killing of cancer cells
P Huang, L Feng, EA Oldham, MJ Keating, W Plunkett - Nature, 2000 - nature.com
Superoxide dismutases (SOD) are essential enzymes that eliminate superoxide radical (O2-
) and thus protect cells from damage induced by free radicals,,. The active O2-production …
) and thus protect cells from damage induced by free radicals,,. The active O2-production …
HIV evolution: CTL escape mutation and reversion after transmission
Within-patient HIV evolution reflects the strong selection pressure driving viral escape from
cytotoxic T-lymphocyte (CTL) recognition. Whether this intrapatient accumulation of escape …
cytotoxic T-lymphocyte (CTL) recognition. Whether this intrapatient accumulation of escape …
Immune control of HIV-1 after early treatment of acute infection
ES Rosenberg, M Altfeld, SH Poon, MN Phillips… - Nature, 2000 - nature.com
Virus-specific T-helper cells are considered critical for the control of chronic viral infections,.
Successful treatment of acute HIV-1 infection leads to augmentation of these responses …
Successful treatment of acute HIV-1 infection leads to augmentation of these responses …
Evidence of HIV-1 adaptation to HLA-restricted immune responses at a population level
CB Moore, M John, IR James, FT Christiansen, CS Witt… - Science, 2002 - science.org
Antigen-specific T cell immunity is HLA-restricted. Human immunodeficiency virus–type 1
(HIV-1) mutations that allow escape from host immune responses may therefore be HLA …
(HIV-1) mutations that allow escape from host immune responses may therefore be HLA …
Cellular immune responses to HIV
AJ McMichael, SL Rowland-Jones - Nature, 2001 - nature.com
The cellular immune response to the human immunodeficiency virus, mediated by T
lymphocytes, seems strong but fails to control the infection completely. In most virus …
lymphocytes, seems strong but fails to control the infection completely. In most virus …
Tat-specific cytotoxic T lymphocytes select for SIV escape variants during resolution of primary viraemia
Human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) infections
are characterized by early peaks of viraemia that decline as strong cellular immune …
are characterized by early peaks of viraemia that decline as strong cellular immune …