Cryptococcosis is an important opportunistic infection and a leading cause of meningitis in
patients with HIV infection. The antifungal pharmacological treatment is limited to …

The blood–brain barrier (BBB) is the protective sheath around the brain that protects the
sensitive microenvironments of the brain. However, certain pathogens, viruses, and bacteria …

Gliomas are the deadliest of all primary brain tumors, and they constitute a serious global
health problem. MicroRNAs (miRNAs) are gene expression regulators associated with …

Alzheimer's disease (AD) is the fifth leading cause of death on the planet. It hallmarks the
presence of amyloid plaques and neurofibrillary tangles in geriatric patients. The condition …

Abstract The World Health Organization (WHO) ranked depression as the third leading
cause of global burden of disease in 2004, and it is predicted to overtake it and move to first …

Aim To prepare polymer-drug conjugates containing a combination of memantine, tacrine,
and E)-N-(3-aminopropyl) cinnamide, promising therapeutics for the treatment of …

Lipid-based nanocarriers such as solid lipid nanoparticles, liposomes, nanoemulsions, and
microemulsions are being explored widely for brain targeting. Nanoemulsions are biphasic …

Schizophrenia is a neuropsychiatric disorder mainly affecting the central nervous system
(CNS), presented with auditory and visual hallucinations, delusion and withdrawal from …

The nasal route of drug administration is utilized for therapeutic applications for decades
due to the facile nasal pathway, non-invasive nature, neuronal connection between brain …

Lipid nano-systems were prepared and characterized in a series of well-established in vitro
tests that could assess their interactions with the hCMEC/D3 and SH-SY5Y cell lines as a …