The aging process worsens the human body functions at multiple levels, thus causing its
gradual decrease to resist stress, damage, and disease. Besides changes in gene …

Background Limitless self-renewal is one of the hallmarks of cancer and is attained by
telomere maintenance, essentially through telomerase (h TERT) activation. Transcriptional …

Idiopathic pulmonary fibrosis (IPF) is a chronic fibrotic lung disease of unknown etiology.
With a gradually increasing worldwide prevalence and a mortality rate exceeding that of …

Simple Summary Poly (ADP-ribose) polymerase (PARP) proteins regulate DNA damage
correction, replication, and gene transcription. By controlling pivotal aspects of these …

Telomeres cap the ends of eukaryotic chromosomes and are indispensable chromatin
structures for genome protection and replication. Telomere length maintenance has been …

Even though clinical, epidemiological and toxicological studies have progressively provided
a better knowledge of the underlying mechanisms by which air pollution-derived particulate …

Telomeres are progressively eroded during repeated rounds of cell division due to the end
replication problem but also undergo additional more substantial stochastic shortening …

Non-small cell lung cancer (NSCLC) is the leading cause of cancer death worldwide
underlining the urgent need for new biomarkers and therapeutic targets for this disease …

Strongly associated with tobacco use, heavy alcohol consumption, and with high-risk human
papillomavirus (HPV) infection, head and neck squamous cell carcinoma (HNSCC) is a …

Nanoporous gold (np-Au) has promising applications in therapeutic delivery. The promises
arise from its high surface area-to-volume ratio, ease of tuning shape and size, ability to be …