Internal membrane bound structures sequester all genetic material in eukaryotic cells. The
most prominent of these structures is the nucleus, which is bounded by a double membrane …

Although the nuclear pore complex (NPC) is best known for its primary function as the key
regulator of molecular traffic between the cytoplasm and the nucleus, a growing body of …

The spatial separation of DNA replication and gene transcription in the nucleus and protein
translation in the cytoplasm is a uniform principle of eukaryotic cells. This …

Proteins in the karyopherin-β family mediate the majority of macromolecular transport
between the nucleus and the cytoplasm. Eleven of the 19 known human karyopherin-βs and …

CRM1 (also known as XPO1 and exportin 1) mediates nuclear export of hundreds of
proteins through the recognition of the leucine-rich nuclear export signal (LR-NES). Here we …

The Karyopherin-β family of proteins mediates nuclear transport of macromolecules. Nuclear
versus cytoplasmic localization of proteins is often suggested by the presence of NLSs …

The nuclear transport proteins, importins and exportins (karyopherin-β proteins), may play
an important role in cancer by transporting key mediators of oncogenesis across the nuclear …

The Karyopherin-β family of nuclear transport factors mediates the majority of
nucleocytoplasmic transport. Although each of the 19 Karyopherin-βs transports unique sets …

Motivation: Classical nuclear export signals (NESs) are short cognate peptides that direct
proteins out of the nucleus via the CRM1-mediated export pathway. CRM1 regulates the …

The leucine-rich nuclear export signal (NES) is the only known class of targeting signal that
directs macromolecules out of the cell nucleus. NESs are short stretches of 8–15 amino …