The transcription factor SOX2 is essential for embryonic development and plays a crucial
role in maintaining the stemness of embryonic cells and various adult stem cell populations …

Fibroblasts synthesize the extracellular matrix of connective tissue and play an essential role
in maintaining the structural integrity of most tissues. Researchers have long suspected that …

Previous studies have shown that mouse dermis is composed of functionally distinct
fibroblast lineages. To explore the extent of fibroblast heterogeneity in human skin, we used …

The use of stem cells has been reported to improve hair regrowth in several therapeutic
strategies, including reversing the pathological mechanisms, that contribute to hair loss …

INTRODUCTION Fibroblasts are the predominant cell type that synthesizes and remodels
the extracellular matrix in organs during both embryonic and adult life and are central to the …

Dermal fibroblasts exhibit considerable heterogeneity during homeostasis and in response
to injury. Defining lineage origins of reparative fibroblasts and regulatory programs that drive …

The skin is the biggest organ of the human being and has many functions. Therefore, the
healing of a skin wound displays an extraordinary mechanism of cascading cellular …

The skin protects mammals from insults, infection and dehydration and enables
thermoregulation and sensory perception. Various skin-resident cells carry out these diverse …

Mammalian wounds typically heal by fibrotic repair without hair follicle (HF) regeneration.
Fibrosis and regeneration are currently considered the opposite end of wound healing. This …

Sox family transcription factors are well-established regulators of cell fate decisions during
development. Accumulating evidence documents that they play additional roles in adult …