Myeloid-derived suppressor cells (MDSC) are a heterogeneous population of pathologically
activated, mostly immature, myeloid cells that exert robust immunosuppressive functions …

Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment by producing
remarkable clinical outcomes for patients with various cancer types. However, only a subset …

Abnormal intracellular metabolism not only provides nutrition for tumor occurrence and
development, but also sensitizes the function of various immune cells in the immune …

Simple Summary The immunosuppressive microenvironment is closely related to the poor
prognosis of patients with PDAC. Tfh cells play an anti-tumor function in various malignant …

Pancreatic ductal adenocarcinoma (PDAC) is a malignancy with a poor prognosis and low
survival rates. PDAC is characterized by a fibroinflammatory tumor microenvironment …

The T cell-mediated immune response is primarily involved in the fight against infectious
diseases and cancer and its underlying mechanisms are complex. The anti-tumor T cell …

Chemotherapy predominates in clinical treatment of prostate cancer (PCa), while
irreversible resistance to chemotherapeutics and severe side effects hinder the therapeutic …

Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature
myeloid cells that are activated under pathological conditions, such as cancer, or mature …

Longevity, functionality, and metabolic fitness are key determinants of chimeric antigen
receptor (CAR) T cell efficacy. Activated T cells follow an ordered differentiation program …

Methods The role and underlying mechanism that MDSCs or exosomes (Exo) regulates the
function of CD8+ T cells were investigated using immunofluorescence, fluorescence …