Solid lipid nanoparticles for drug delivery: pharmacological and biopharmaceutical aspects

S Scioli Montoto, G Muraca, ME Ruiz - Frontiers in molecular …, 2020 - frontiersin.org
In the golden age of pharmaceutical nanocarriers, we are witnessing a maturation stage of
the original concepts and ideas. There is no doubt that nanoformulations are extremely …

The landscape of nanoparticle-based siRNA delivery and therapeutic development

M Moazzam, M Zhang, A Hussain, X Yu, J Huang… - Molecular Therapy, 2024 - cell.com
Five small interfering RNA (siRNA)-based therapeutics have been approved by the Food
and Drug Administration (FDA), namely patisiran, givosiran, lumasiran, inclisiran, and …

Nanostructured particles assembled from natural building blocks for advanced therapies

Y Ju, H Liao, JJ Richardson, J Guo… - Chemical Society …, 2022 - pubs.rsc.org
Advanced treatments based on immune system manipulation, gene transcription and
regulation, specific organ and cell targeting, and/or photon energy conversion have …

Physiological barriers and strategies of lipid‐based nanoparticles for nucleic acid drug delivery

M Hu, X Li, Z You, R Cai, C Chen - Advanced Materials, 2024 - Wiley Online Library
Lipid‐based nanoparticles (LBNPs) are currently the most promising vehicles for nucleic
acid drug (NAD) delivery. Although their clinical applications have achieved success, the …

Recent advances in siRNA delivery mediated by lipid-based nanoparticles

S Yonezawa, H Koide, T Asai - Advanced drug delivery reviews, 2020 - Elsevier
Small interfering RNA (siRNA) has been expected to be a unique pharmaceutic for the
treatment of broad-spectrum intractable diseases. However, its unfavorable properties such …

Nanotoxicology applied to solid lipid nanoparticles and nanostructured lipid carriers–a systematic review of in vitro data

S Doktorovova, EB Souto, AM Silva - European Journal of Pharmaceutics …, 2014 - Elsevier
Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) were developed as
alternative to other colloidal carriers. They were designed to overcome lipid nanoemulsions …

The impact of variables on particle size of solid lipid nanoparticles and nanostructured lipid carriers; a comparative literature review

LAS Bahari, H Hamishehkar - Advanced pharmaceutical …, 2016 - pmc.ncbi.nlm.nih.gov
During the past decade, pharmaceutical science has seen rapid growth in interest for
nanoscale materials. Solid lipid nanoparticles (SLNs) and nanostructured lipid carriers …

[HTML][HTML] siRNA therapeutics and its challenges: recent advances in effective delivery for cancer therapy

A Paul, A Muralidharan, A Biswas, BV Kamath… - OpenNano, 2022 - Elsevier
Small interfering RNA (siRNA) has emerged as a promising strategy for treating several
“undruggable” genetically impaired conditions. The siRNA-based drugs have opened the …

Solid lipid nanoparticles: a promising nanomaterial in drug delivery

K Rajpoot - Current pharmaceutical design, 2019 - benthamdirect.com
The solid lipid nanoparticles (SLNs) usually consists of active drug molecules along with
solid lipids, surfactants, and/or co-surfactants. They possess some potential features such as …

In vivo photoacoustic imaging of livers using biodegradable hyaluronic acid‐conjugated silica nanoparticles

D Lee, S Beack, J Yoo, SK Kim, C Lee… - Advanced Functional …, 2018 - Wiley Online Library
The diagnosis of liver diseases is generally carried out via ultrasound imaging, computed
tomography, and magnetic resonance imaging. The emerging photoacoustic imaging is an …