Cortical circuits in the brain are refined by experience during critical periods early in
postnatal life. Critical periods are regulated by the balance of excitatory and inhibitory (E/I) …

Joint profiling of chromatin accessibility and gene expression in individual cells provides an
opportunity to decipher enhancer-driven gene regulatory networks (GRNs). Here we present …

Neuronal migration in the cortex is controlled by the paracrine action of the classical
neurotransmitters glutamate and GABA. Glutamate controls radial migration of pyramidal …

Diverse subsets of cortical interneurons have vital roles in higher-order brain functions. To
investigate how this diversity is generated, here we used single-cell RNA sequencing to …

Neural circuits are shaped by experience in early postnatal life. Distinct GABAergic
connections within visual cortex determine the timing of the critical period for rewiring ocular …

In subjects with schizophrenia, impairments in working memory are associated with
dysfunction of the dorsolateral prefrontal cortex (DLPFC). This dysfunction appears to be …

Maternal immune activation (MIA) is a risk factor for the development of schizophrenia and
autism. Infections during pregnancy activate the mother's immune system and alter the fetal …

Fast-spiking (FS) interneurons are important elements of neocortical circuitry that constitute
the primary source of synaptic inhibition in adult cortex and impart temporal organization on …

Mammalian pallial (cortical and hippocampal) and striatal interneurons are both generated
in the embryonic subpallium, including the medial ganglionic eminence (MGE). Herein we …

Although previous work identified transcription factors crucial for the specification and
migration of parvalbumin (PV)-expressing and somatostatin (SST)-expressing interneurons …