Hippo signaling pathway is an evolutionarily conserved network that regulates organ size
growth and tissue regeneration. Hippo signaling dysfunction results in uncontrolled cell …

Yes-Associated Protein (YAP) and Transcriptional Co-activator with PDZ-binding Motif (TAZ)
have both emerged as important drivers of cancer progression and metastasis. YAP and …

Background As a subclass of noncoding RNAs, circular RNAs (circRNAs) have been
demonstrated to play a critical role in regulating gene expression in eukaryotes. Recent …

YAP and TAZ are intracellular messengers communicating multiple interacting extracellular
biophysical and biochemical cues to the transcription apparatus in the nucleus and back to …

Background There is an urgent need to identify new molecular targets for treatment of
osteosarcoma. Circular RNAs are a class of endogenous RNAs that are extensively found in …

Diffuse large B cell lymphoma (DLBCL) is a common and fatal hematological malignancy.
Long noncoding RNAs (lncRNAs) have emerged as crucial biomarkers and regulators in …

Studies over the past four decades have elucidated the role of Wnt/β-catenin mediated
regulation in cell proliferation, differentiation and migration. These processes are …

Osteoarthritis (OA) is a common, age-related, and painful disease characterized by cartilage
destruction, osteophyte formation, and synovial hyperplasia. This study revealed that …

Osteosarcoma is one of the most prevalent primary bone tumors with a high metastatic and
recurrence rate with poor prognosis. MiRNAs are short and non-coding RNAs that could …

Solid tumors are dependent on vascularization for their growth. The hypoxic, stiff, and pro-
angiogenic tumor microenvironment induces angiogenesis, giving rise to an immature …