Modelling cancer in microfluidic human organs-on-chips
A Sontheimer-Phelps, BA Hassell, DE Ingber - Nature Reviews Cancer, 2019 - nature.com
One of the problems that has slowed the development and approval of new anticancer
therapies is the lack of preclinical models that can be used to identify key molecular, cellular …
therapies is the lack of preclinical models that can be used to identify key molecular, cellular …
Microfluidic chips: recent advances, critical strategies in design, applications and future perspectives
Microfluidic chip technology is an emerging tool in the field of biomedical application.
Microfluidic chip includes a set of groves or microchannels that are engraved on different …
Microfluidic chip includes a set of groves or microchannels that are engraved on different …
Microfluidic organ-on-chip system for multi-analyte monitoring of metabolites in 3D cell cultures
Three-dimensional cell cultures using patient-derived stem cells are essential in vitro
models for a more efficient and individualized cancer therapy. Currently, culture conditions …
models for a more efficient and individualized cancer therapy. Currently, culture conditions …
Print me an organ! Why we are not there yet
Bioprinting offers a highly-automated and advanced manufacturing platform that facilitates
the deposition of bio-inks (living cells, biomaterials and growth factors) in a scalable and …
the deposition of bio-inks (living cells, biomaterials and growth factors) in a scalable and …
Beating heart on a chip: a novel microfluidic platform to generate functional 3D cardiac microtissues
A Marsano, C Conficconi, M Lemme, P Occhetta… - Lab on a Chip, 2016 - pubs.rsc.org
In the past few years, microfluidic-based technology has developed microscale models
recapitulating key physical and biological cues typical of the native myocardium. However …
recapitulating key physical and biological cues typical of the native myocardium. However …
Engineering of functional, perfusable 3D microvascular networks on a chip
Generating perfusable 3D microvessels in vitro is an important goal for tissue engineering,
as well as for reliable modelling of blood vessel function. To date, in vitro blood vessel …
as well as for reliable modelling of blood vessel function. To date, in vitro blood vessel …
Three-dimensional microfluidic model for tumor cell intravasation and endothelial barrier function
Entry of tumor cells into the blood stream is a critical step in cancer metastasis. Although
significant progress has been made in visualizing tumor cell motility in vivo, the underlying …
significant progress has been made in visualizing tumor cell motility in vivo, the underlying …
Engineered in vitro disease models
The ultimate goal of most biomedical research is to gain greater insight into mechanisms of
human disease or to develop new and improved therapies or diagnostics. Although great …
human disease or to develop new and improved therapies or diagnostics. Although great …
Microfluidic modelling of the tumor microenvironment for anti-cancer drug development
Cancer is the leading cause of death worldwide. The complex and disorganized tumor
microenvironment makes it very difficult to treat this disease. The most common in vitro drug …
microenvironment makes it very difficult to treat this disease. The most common in vitro drug …
Thin, soft, skin‐mounted microfluidic networks with capillary bursting valves for chrono‐sampling of sweat
Systems for time sequential capture of microliter volumes of sweat released from targeted
regions of the skin offer the potential to enable analysis of temporal variations in electrolyte …
regions of the skin offer the potential to enable analysis of temporal variations in electrolyte …