Glial fibrillary acidic protein (GFAP) is the main intermediate filament protein in mature
astrocytes, but also an important component of the cytoskeleton in astrocytes during …

Adeno-associated viral (AAV) vectors are a rapidly emerging gene therapy platform for the
treatment of neurological diseases. In preclinical studies, transgenes encoding therapeutic …

Adeno-associated viruses (AAVs) are commonly used for in vivo gene transfer.
Nevertheless, AAVs that provide efficient transduction across specific organs or cell …

In vivo cell fate conversions have emerged as potential regeneration-based therapeutics for
injury and disease. Recent studies reported that ectopic expression or knockdown of certain …

Astrocytes are glial cells that are abundant in the central nervous system (CNS) and that
have important homeostatic and disease-promoting functions. However, little is known about …

Multiple sclerosis is a chronic inflammatory disease of the CNS. Astrocytes contribute to the
pathogenesis of multiple sclerosis, but little is known about the heterogeneity of astrocytes …

INTRODUCTION Glial cells of the central nervous system (CNS), including astrocytes and
microglia, play critical roles in development, tissue repair, and homeostasis. However …

Perisynaptic astrocytic processes are an integral part of central nervous system synapses,;
however, the molecular mechanisms that govern astrocyte–synapse adhesions and how …

Investigating lactate dynamics in brain tissue is challenging, partly because in vivo data at
cellular resolution are not available. We monitored lactate in cortical astrocytes and neurons …

Alzheimer's disease (AD) is characterized by the accumulation of the tau protein in neurons,
neurodegeneration and memory loss. However, the role of non-neuronal cells in this chain …