Amyloid oligomers: A joint experimental/computational perspective on Alzheimer's disease, Parkinson's disease, type II diabetes, and amyotrophic lateral sclerosis
Protein misfolding and aggregation is observed in many amyloidogenic diseases affecting
either the central nervous system or a variety of peripheral tissues. Structural and dynamic …
either the central nervous system or a variety of peripheral tissues. Structural and dynamic …
Proteostasis of islet amyloid polypeptide: a molecular perspective of risk factors and protective strategies for type II diabetes
The possible link between hIAPP accumulation and β-cell death in diabetic patients has
inspired numerous studies focusing on amyloid structures and aggregation pathways of this …
inspired numerous studies focusing on amyloid structures and aggregation pathways of this …
Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis
The mixed lineage kinase domain-like protein (MLKL) has recently been identified as a key
RIP3 (receptor interacting protein 3) downstream component of tumour necrosis factor (TNF) …
RIP3 (receptor interacting protein 3) downstream component of tumour necrosis factor (TNF) …
Structure based aggregation studies reveal the presence of helix-rich intermediate during α-Synuclein aggregation
Mechanistic understanding of nucleation dependent polymerization by α-synuclein (α-Syn)
into toxic oligomers and amyloids is important for the drug development against Parkinson's …
into toxic oligomers and amyloids is important for the drug development against Parkinson's …
Protein folding and aggregation into amyloid: the interference by natural phenolic compounds
M Stefani, S Rigacci - International journal of molecular sciences, 2013 - mdpi.com
Amyloid aggregation is a hallmark of several degenerative diseases affecting the brain or
peripheral tissues, whose intermediates (oligomers, protofibrils) and final mature fibrils …
peripheral tissues, whose intermediates (oligomers, protofibrils) and final mature fibrils …
Graphene quantum dots against human IAPP aggregation and toxicity in vivo
The development of biocompatible nanomaterials has become a new frontier in the
detection, treatment and prevention of human amyloid diseases. Here we demonstrated the …
detection, treatment and prevention of human amyloid diseases. Here we demonstrated the …
[HTML][HTML] Amyloid growth and membrane damage: Current themes and emerging perspectives from theory and experiments on Aβ and hIAPP
Alzheimer's Disease (AD) and Type 2 diabetes mellitus (T2DM) are two incurable diseases
both hallmarked by an abnormal deposition of the amyloidogenic peptides Aβ and Islet …
both hallmarked by an abnormal deposition of the amyloidogenic peptides Aβ and Islet …
[HTML][HTML] Impact of membrane curvature on amyloid aggregation
MS Terakawa, Y Lin, M Kinoshita, S Kanemura… - … et Biophysica Acta (BBA …, 2018 - Elsevier
The misfolding, amyloid aggregation, and fibril formation of intrinsically disordered
proteins/peptides (or amyloid proteins) have been shown to cause a number of disorders …
proteins/peptides (or amyloid proteins) have been shown to cause a number of disorders …
[HTML][HTML] Recent advances in the molecular genetics of type 2 diabetes mellitus
Type 2 diabetes mellitus (T2DM) is a complex disease in which both genetic and
environmental factors interact in determining impaired β-cell insulin secretion and peripheral …
environmental factors interact in determining impaired β-cell insulin secretion and peripheral …
Islet amyloid polypeptide membrane interactions: effects of membrane composition
Amyloid formation by islet amyloid polypeptide (IAPP) contributes to β-cell dysfunction in
type 2 diabetes. Perturbation of the β-cell membrane may contribute to IAPP-induced …
type 2 diabetes. Perturbation of the β-cell membrane may contribute to IAPP-induced …