Adult neurogenesis in the dentate gyrus of the hippocampus is highly regulated by a number
of environmental and cell-intrinsic factors to adapt to environmental changes. Accumulating …

Depression represents a global mental health concern, and disproportionally affects women
as they are twice more likely to be diagnosed than men. In this review, we provide a …

Adult hippocampal neurogenesis has been implicated in cognitive processes, such as
pattern separation, and in the behavioural effects of stress and antidepressants. Young adult …

Now 30 years old, the chronic mild stress (CMS) model of depression has been used in>
1300 published studies, with a year-on-year increase rising to> 200 papers in 2015. Data …

Background: Among the many cannabinoids in the cannabis plant, cannabidiol (CBD) is a
compound that does not produce the typical subjective effects of marijuana. Objectives: The …

The hippocampus provided the gateway into much of what we have learned about stress
and brain structural and functional plasticity, and this initial focus has expanded to other …

An estimated 50% of depressed patients are inadequately treated by available interventions.
Even with an eventual recovery, many patients require a trial and error approach, as there …

Depression is an episodic form of mental illness characterized by mood state transitions with
poorly understood neurobiological mechanisms. Antidepressants reverse the effects of …

This article is part of a Special Issue “Parental Care”. Pregnancy and postpartum are
associated with dramatic alterations in steroid and peptide hormones which alter the …

Major depressive disorder (MDD) is a highly prevalent psychiatric disorder and a major
cause of disability worldwide. This neurological condition is commonly associated with …